Laboratory Investigations

Calcified Tissue International

, Volume 37, Issue 4, pp 411-417

First online:

Regulation of bone mass by mechanical strain magnitude

  • Clinton T. RubinAffiliated withDepartment of Anatomy and Cellular Biology, Tufts University
  • , Lance E. LanyonAffiliated withDepartment of Anatomy and Cellular Biology, Tufts University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Thein vivo remodeling behavior within a bone protected from natural loading was modified over an 8-week period by daily application of 100 consecutive 1 Hz load cycles engendering strains within the bone tissue of physiological rate and magnitude. This load regime resulted in a graded dose:response relationship between the peak strain magnitude and change in the mass of bone tissue present. Peak longitudinal strains below 0.001 were associated with bone loss which was achieved by increased remodeling activity, endosteal resorption, and increased intra-cortical porosis. Peak strains above 0.001 were associated with little change in intra-cortical remodeling activity but substantial periosteal and endosteal new bone formation.

Key words

Bone remodeling Mechanical strain Osteoporosis Bone mass