Diseases of the Colon & Rectum

, Volume 31, Issue 6, pp 459–461

Treatment of desmoid tumors in Gardner's syndrome

Report of a case

Authors

  • Hideaki Itoh
    • Department of Surgery IKyushu University Faculty of Medicine
    • Department of Internal Medicine IIKyushu University Faculty of Medicine
    • Department of Pathology IIKyushu University Faculty of Medicine
    • Department of RadiologyKyushu University Faculty of Medicine
  • Shinichi Ikeda
    • Department of Surgery IKyushu University Faculty of Medicine
    • Department of Internal Medicine IIKyushu University Faculty of Medicine
    • Department of Pathology IIKyushu University Faculty of Medicine
    • Department of RadiologyKyushu University Faculty of Medicine
  • Yoshihiro Oohata
    • Department of Surgery IKyushu University Faculty of Medicine
    • Department of Internal Medicine IIKyushu University Faculty of Medicine
    • Department of Pathology IIKyushu University Faculty of Medicine
    • Department of RadiologyKyushu University Faculty of Medicine
  • Mitsuo Iida
    • Department of Surgery IKyushu University Faculty of Medicine
    • Department of Internal Medicine IIKyushu University Faculty of Medicine
    • Department of Pathology IIKyushu University Faculty of Medicine
    • Department of RadiologyKyushu University Faculty of Medicine
  • Tatsunori Inoue
    • Department of Surgery IKyushu University Faculty of Medicine
    • Department of Internal Medicine IIKyushu University Faculty of Medicine
    • Department of Pathology IIKyushu University Faculty of Medicine
    • Department of RadiologyKyushu University Faculty of Medicine
  • Hideo Onitsuka
    • Department of Surgery IKyushu University Faculty of Medicine
    • Department of Internal Medicine IIKyushu University Faculty of Medicine
    • Department of Pathology IIKyushu University Faculty of Medicine
    • Department of RadiologyKyushu University Faculty of Medicine
Article

DOI: 10.1007/BF02552617

Cite this article as:
Itoh, H., Ikeda, S., Oohata, Y. et al. Dis Colon Rectum (1988) 31: 459. doi:10.1007/BF02552617

Abstract

Aggressive desmoid tumors present difficult problems among patients with Gardner's syndrome. Recently, attention has been directed toward metabolic or hormonal manipulation of these tumors. A 21-year-old woman with Gardner's syndrome was admitted because of recurrent abdominal wall tumors. She was treated with nonsteroidal anti-inflammatory drugs, tamoxifen, and ascorbate for seven months. During this therapy, CT scan showed a gradual increase in size of the tumors. Subsequent resection of the abdominal tumors and the colon was performed. Although these three types of drugs were administered to prevent postoperative recurrence, an abdominal wall desmoid tumor that invaded the mesentery developed within nine months. The known treatments, that is, chemotherapy, irradiation, and surgical resection are discussed in view of this experience.

Key words

Desmoid tumorFibromatosisGardner's syndromeAnti-inflammatory drugs

Copyright information

© American Society of Colon and Rectal Surgeons 1988