Article

Diseases of the Colon & Rectum

, Volume 31, Issue 6, pp 459-461

Treatment of desmoid tumors in Gardner's syndrome

Report of a case
  • Hideaki ItohAffiliated withDepartment of Surgery I, Kyushu University Faculty of MedicineDepartment of Internal Medicine II, Kyushu University Faculty of MedicineDepartment of Pathology II, Kyushu University Faculty of MedicineDepartment of Radiology, Kyushu University Faculty of Medicine
  • , Shinichi IkedaAffiliated withDepartment of Surgery I, Kyushu University Faculty of MedicineDepartment of Internal Medicine II, Kyushu University Faculty of MedicineDepartment of Pathology II, Kyushu University Faculty of MedicineDepartment of Radiology, Kyushu University Faculty of Medicine
  • , Yoshihiro OohataAffiliated withDepartment of Surgery I, Kyushu University Faculty of MedicineDepartment of Internal Medicine II, Kyushu University Faculty of MedicineDepartment of Pathology II, Kyushu University Faculty of MedicineDepartment of Radiology, Kyushu University Faculty of Medicine
  • , Mitsuo IidaAffiliated withDepartment of Surgery I, Kyushu University Faculty of MedicineDepartment of Internal Medicine II, Kyushu University Faculty of MedicineDepartment of Pathology II, Kyushu University Faculty of MedicineDepartment of Radiology, Kyushu University Faculty of Medicine
  • , Tatsunori InoueAffiliated withDepartment of Surgery I, Kyushu University Faculty of MedicineDepartment of Internal Medicine II, Kyushu University Faculty of MedicineDepartment of Pathology II, Kyushu University Faculty of MedicineDepartment of Radiology, Kyushu University Faculty of Medicine
  • , Hideo OnitsukaAffiliated withDepartment of Surgery I, Kyushu University Faculty of MedicineDepartment of Internal Medicine II, Kyushu University Faculty of MedicineDepartment of Pathology II, Kyushu University Faculty of MedicineDepartment of Radiology, Kyushu University Faculty of Medicine

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Abstract

Aggressive desmoid tumors present difficult problems among patients with Gardner's syndrome. Recently, attention has been directed toward metabolic or hormonal manipulation of these tumors. A 21-year-old woman with Gardner's syndrome was admitted because of recurrent abdominal wall tumors. She was treated with nonsteroidal anti-inflammatory drugs, tamoxifen, and ascorbate for seven months. During this therapy, CT scan showed a gradual increase in size of the tumors. Subsequent resection of the abdominal tumors and the colon was performed. Although these three types of drugs were administered to prevent postoperative recurrence, an abdominal wall desmoid tumor that invaded the mesentery developed within nine months. The known treatments, that is, chemotherapy, irradiation, and surgical resection are discussed in view of this experience.

Key words

Desmoid tumor Fibromatosis Gardner's syndrome Anti-inflammatory drugs