Diseases of the Colon & Rectum

, Volume 31, Issue 6, pp 459–461

Treatment of desmoid tumors in Gardner's syndrome

Report of a case
  • Hideaki Itoh
  • Shinichi Ikeda
  • Yoshihiro Oohata
  • Mitsuo Iida
  • Tatsunori Inoue
  • Hideo Onitsuka
Article

DOI: 10.1007/BF02552617

Cite this article as:
Itoh, H., Ikeda, S., Oohata, Y. et al. Dis Colon Rectum (1988) 31: 459. doi:10.1007/BF02552617
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Abstract

Aggressive desmoid tumors present difficult problems among patients with Gardner's syndrome. Recently, attention has been directed toward metabolic or hormonal manipulation of these tumors. A 21-year-old woman with Gardner's syndrome was admitted because of recurrent abdominal wall tumors. She was treated with nonsteroidal anti-inflammatory drugs, tamoxifen, and ascorbate for seven months. During this therapy, CT scan showed a gradual increase in size of the tumors. Subsequent resection of the abdominal tumors and the colon was performed. Although these three types of drugs were administered to prevent postoperative recurrence, an abdominal wall desmoid tumor that invaded the mesentery developed within nine months. The known treatments, that is, chemotherapy, irradiation, and surgical resection are discussed in view of this experience.

Key words

Desmoid tumorFibromatosisGardner's syndromeAnti-inflammatory drugs

Copyright information

© American Society of Colon and Rectal Surgeons 1988

Authors and Affiliations

  • Hideaki Itoh
    • 1
    • 2
    • 3
    • 4
  • Shinichi Ikeda
    • 1
    • 2
    • 3
    • 4
  • Yoshihiro Oohata
    • 1
    • 2
    • 3
    • 4
  • Mitsuo Iida
    • 1
    • 2
    • 3
    • 4
  • Tatsunori Inoue
    • 1
    • 2
    • 3
    • 4
  • Hideo Onitsuka
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of Surgery IKyushu University Faculty of MedicineFukuokaJapan
  2. 2.Department of Internal Medicine IIKyushu University Faculty of MedicineFukuokaJapan
  3. 3.Department of Pathology IIKyushu University Faculty of MedicineFukuokaJapan
  4. 4.Department of RadiologyKyushu University Faculty of MedicineFukuokaJapan