Abstract
In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time.
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Born, G. V. R.: Aggregation of blood platelets by adenosine diphosphate.Nature, 194, 927 (1962).
Breddin, K., Krzywanek, H. J., Bald, M., Kutschera, J.: Platelet aggregation control: clinical potential. In: Platelet Aggregation and Drugs. Academic Press, London 1974, p. 197.
Dworski, R., Domagała, B., Hartwich, J., Radwan, J., Grzywacz, M., Szeczeklik, A.: Vitamin E effect on plasma lipid peroxides and platelet aggregation in patients with hyperlipoproteinaemia.Pol. Arch. Med. Wewn., 393, 75 (1986).
Fitzgerald, G. A., Brash, A. R.: Endogenous prostacyclin and thromboxane biosynthesis during chronic vitamin E therapy in man.Ann. N.Y. Acad. Sci., 324, 209 (1982).
Graham, F. F., Wallis, R. B., Zelaschi, D.: The effect of sulphinpyrazone and its metabolites on platelet function in vitro and ex vivo.Haemostasis, 10, 165 (1981).
Huang, N., Lineberger, B., Steiner, M.: Alpha-tocopherol, a potent modulator of endothelial cell function.Thromb. Res., 50, 547 (1988).
Karpen, C. W., Pritchard, K. A., Arnold, J. H., Cornell, D. G., Parganamala, R. V.: Restoration of prostacyclin thromboxane A2 balance in the diabetic rat: influence of dietary vitamin E.Diabetes, 31, 947 (1982).
Lucy, J. A.: Functional and structural aspects of biological membranes. A suggested structural role for vitamin E in the control of membrane permeability and stability.Ann. N.Y. Acad. Sci., 4, 203 (1972).
Mielke, C. H.: Template bleeding time: technique. In: Platelet Function Testing. DHEW Publications, (NIH) 78-1087, 1977, p. 723.
Miesher, P. A., Gerard, W. H.: A one-step method for counting the leukocytes and platelets.Am. J. Clin. Pathol., 46, 576 (1966).
O'Brien, J. R., Etherington, M. D.: Heparin-thrombin clotting time and platelet factor 4.Lancet, 1, 656 (1974).
Preston, F. E., Greaves, M.: Platelet suppressive therapy in clinical medicine.Br. J. Haematol., 60, 589 (1985).
Saleem, A., Krieg, A., Cieślica, R.: Platelet activity ratio.Am. J. Clin. Pathol., 232, 1303 (1975).
Steiner, M., Anastasi, J.: Vitamin E—an inhibitor of platelet release reaction.J. Clin. Invest., 57, 752 (1976).
Steiner, M.: Effect of alpha-tocopherol administration on platelet function in man.Thromb. Haemost., 49, 73 (1983).
Szezeklik, A., Gryglewski, R. J., Domagała, B., Dworski, R., Basista, M.: Dietary supplementation with vitamin E in hyperlipoproteinemias. Effect on plasma lipid peroxides, antioxidant activity, prostacyclin generation and platelet aggregation.Thromb. Haemost., 54, 425 (1985).
Watanabe, J., Umeda, F., Wakasugi, H., Ibayashi, H.: Effect of vitamin E on platelet aggregation in diabetes mellitus.Thromb. Haemost., 51, 313 (1984).
Wu, K. K., Hoak, J. C.: A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency.Lancet, 2, 924 (1974).
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Dmoszyńska-Giannopoulou, A., Janicka, L., Sokołowska, B. et al. The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients. International Urology and Nephrology 22, 561–566 (1990). https://doi.org/10.1007/BF02549745
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DOI: https://doi.org/10.1007/BF02549745