Article

International Urology and Nephrology

, Volume 22, Issue 6, pp 561-566

The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients

  • A. Dmoszyńska-GiannopoulouAffiliated withDepartment of Haematology and Nephrology, Medical School
  • , L. JanickaAffiliated withDepartment of Haematology and Nephrology, Medical School
  • , B. SokołowskaAffiliated withDepartment of Haematology and Nephrology, Medical School
  • , A. Ksi⇂żekAffiliated withDepartment of Haematology and Nephrology, Medical School
  • , G. OrłowskaAffiliated withDepartment of Haematology and Nephrology, Medical School
  • , K. JanickiAffiliated withDepartment of Haematology and Nephrology, Medical School

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time.