The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients
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- Dmoszyńska-Giannopoulou, A., Janicka, L., Sokołowska, B. et al. International Urology and Nephrology (1990) 22: 561. doi:10.1007/BF02549745
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In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time.