Annals of Surgical Oncology

, Volume 11, Supplement 3, pp 208S–210S

NSABP-32: Phase III, randomized trial comparing axillary resection with sentinal lymph node dissection: A description of the trial

  • David N. Krag
  • Thomas B. Julian
  • Seth P. Harlow
  • Donald L. Weaver
  • Taka Ashikaga
  • John Bryant
  • Richard M. Single
  • Norman Wolmark
Article

DOI: 10.1007/BF02523630

Cite this article as:
Krag, D.N., Julian, T.B., Harlow, S.P. et al. Annals of Surgical Oncology (2004) 11: 208S. doi:10.1007/BF02523630
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Abstract

The NSABP-32 trial is a randomized, phase III clinical trial to compare sentinel node (SN) resection to conventional axillary dissection in clinically node-negative breast cancer patients. The primary aims of the trial are to determine if removal of only SNs provides survival and regional control equivalent to those of axillary dissection, while diminishing the magnitude of surgically related side effects. In order to ensure consistency of the outcomes for this trial, a standardized method of SN surgery has been utilized for all cases. A secondary aim of the B32 trial is to evaluate whether patients with “occult” metastases in the SNs have worse survival. Accrual is taking place at 73 institutions in North America, and 217 surgeons are enrolling patients.

Key Words

Breast cancerClinical trialSentinel nodeSurvival

Copyright information

© The Society of Surgical Oncology, Inc. 2004

Authors and Affiliations

  • David N. Krag
    • 1
  • Thomas B. Julian
    • 3
  • Seth P. Harlow
    • 1
  • Donald L. Weaver
    • 2
  • Taka Ashikaga
    • 3
  • John Bryant
    • 4
  • Richard M. Single
    • 2
  • Norman Wolmark
    • 3
  1. 1.Department of Surgery, College of MedicineUniversity of VermontBurlington
  2. 2.Department of Pathology and Medical Statistics, College of MedicineUniversity of VermontBurlington
  3. 3.National Surgical Breast and Bowel ProjectPittsburgh
  4. 4.Uiversity of PittsburghPittsburgh