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Some considerations on capillary adjustment to changing metabolism of tissue

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Abstract

Local regulation of blood flow as determined by capillary diameter and the number of open capillaries in a region is considered. The local changes in capillary diameter and in the number of open capillaries are assumed to be due to concentration changes of a diffusible, nonspecified metabolite. This metabolite is produced in the tissue and carried away by the blood stream.

Using these assumptions and applying pertinent data on capillaries, deductions are made concerning:

  1. (a)

    the law of blood flow as a function of temperature and capillary radius for the hyperemia of high temperature,

  2. (b)

    high flow as it depends on metabolism during strenuous exercise of muscle, and

  3. (c)

    a first approximation to the time duration of occlusion hyperemia.

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Authors and Affiliations

  1. The University of Chicago, Committee on Mathematical Biology, USA

    David L. Cohn

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  1. David L. Cohn
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Cohn, D.L. Some considerations on capillary adjustment to changing metabolism of tissue. Bulletin of Mathematical Biophysics 15, 93–101 (1953). https://doi.org/10.1007/BF02476371

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  • DOI: https://doi.org/10.1007/BF02476371

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