Abstract
A computational model to predict deposition of a wide variety of particulate pollutants in several species of mammals is presented. The model incorporates breathing pattern and detailed anatomical models of the respiratory tract based on extensive morphometric measurements of individual airways. The predicted deposition from this general model is in close agreement with observed deposition of monodisperse aerosols in rats. Particle size and density and respiratory breathing patterns are the critical parameters affecting regional deposition.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature
Beeckmans, J. M. 1965. “The Deposition of Aerosols in the Respiratory Tract—I. Mathematical Analysis and Comparison with Experimental Data”.Can. J. Physiol. Pharmacol.,43, 157–172.
Bell, K. A. and S. K. Friedlander. 1973. “Aerosol Deposition in Models of a Human Lung Bifurcation”.Staub,33, 183–187.
Davies, C. N. 1972. “Breathing of Half-micron Aerosol—II Interpretation of Experimental Results”.J. Appl. Physiol.,32, 601–611.
Ingham, D. B. 1975. “Diffusion of Aerosols from a Stream Flowing through a Cylindrical Tube”.Aerosol. Sci. 6, 125–132.
Landahl, H. D. 1950. “On the Removal of Air-Borne Droplets by the Human Respiratory Tract—I. The Lung”.Bull. Math. Biophys.,12, 43–56.
Landahl, H. D., 1963. “Particle Removal by the Respiratory System. Note on the Removal of Airborne Particulates by the Human Respiratory Tract with Particular Reference to the Role of Diffusion”.Bull. Math. Biophys.,25, 29–39.
Lippmann, M. 1977. “Regional Deposition of Particles in the Human Respiratory Tract”. InHandbook of Physiology, Section 9: Reactions to Environmental Agents. (Lee, D. H. K., Ed.). Bethesda, Md., American Physiological Society, pp. 213–232.
Marshall, R. and W. S. Holden. 1963. “Changes in Calibre of the Smaller Airways in Man”.Thorax,18, 54–58.
Phalen, R. F., H. C. Yeh, G. M. Schum and O. G. Raabe. 1978. “Application of an Idealized Model to Morphometry of the Mammalian Tracheobronchial Tree”.Anat. Rec.,190, 167–176.
Raabe, O. G. 1976. “Aerosol Aerodynamic Size Conventions for Inertial Sampler Calibration”.J. Air Pollut. Contr. Assoc.,26, 856–860.
Raabe, O. G., H. C. Yeh, G. J. Newton, R. F. Phalen and D. J. Velasquez, 1977. “Deposition of Inhaled Monodisperse Aerosols in Small Rodents”. In:Inhaled Particles. IV. (Walton, W. H., Ed.) New York: Pergamon Press.
Sneddon, S. L., J. D. Brain, S. R. LeMott and P. A. Valberg. 1978. “Factors Influencing Aerosol Deposition in Small Animals”.Fed. Proc. 37, 927 (abstract).
Stahl, W. R. 1967. “Scaling of Respiratory Variables in Mammals”.J. Appl. Physiol.,22, 453–460.
Task Group on Lung Dynamics. 1966. “Deposition and Retention Models for Internal Dosimetry of the Human Respiratory Tract”.Health Phys.,12, 173–207.
Taulbee, D. B. and C. P. Yu. 1975. “A Theory of Aerosol Deposition in the Human Respiratory Tract”.J. Appl. Physiol.,38, 77–85.
Weibel, E. R. 1963.Morphometry of the Human Lung. New York: Academic Press.
Yeh, H. C. 1974. “Use of a Heat Transfer Analogy for a Mathematical Model of Respiratory Tract Deposition”.Bull. Math. Biol.,36, 105–116.
Yeh, H. C., A. J. Hulbert, R. F. Phalen, D. J. Velasquez and T. D. Harris. 1975. “A Stereoradiographic Technique and its Application to the Evaluation of Lung Casts”.Invest. Radiol.,10, 351–357.
Yeh, H. C., R. F. Phalen and O. G. Raabe, 1976. “Factors Influencing the Deposition of Inhaled Particles”.Envir. Hlth Persp.,15, 147–156.
Yeh, H. C., G. M. Schum and M. T. Duggan. 1978. “Models of Tracheobronchial Geometry in the Rat”. Submitted toAnat. Rec.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schum, M., Yeh, HC. Theoretical evaluation of aerosol deposition in anatomical models of mammalian lung airways. Bltn Mathcal Biology 42, 1–15 (1980). https://doi.org/10.1007/BF02462363
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02462363