Abstract
A mathematical model was developed in order to investigate the possible role of the modified Ca permeability through the muscle membrane in the genesis of myotonic state. It was demonstrated that the existence of such possibilities and their corresponding characteristics in terms of various membrane parameters have been defined.
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Literature
Adrian, H. and L. D. Peachey. 1973. “Reconstruction of the action potential of frog sartorius muscle”.J. Physiol. 235, 103–131.
Adrian, H. and S. H. Bryant. 1974. “On the repetitive discharge in myotonic muscle fibres”.J. Physiol.,240, 505–515.
Bianchi, C. P. and A. M. Shanes. 1959. “Calcium influx in skeletal muscle at rest, during activity, and during potassium contracture”.J. Gen. Physiol.,42, 803–815.
Bretag, A. H. 1973. “Mathematical modelling of the myotonic action potential”. InNew Developments in Electromyography and Clinical Neurophysiology, Ed. J. E. Desmedts, pp. 464–482. Basel: S. Karger.
Bryant, S. H. and A. Morales-Aguilera. 1971. “Chloride conductance in normal and myotonic muscle fibres and the action of monocarboxylic aromatic acids”.J., Physiol.,219, 367–383.
— 1973. “The electrophysiology of myotonia, with a review of congenital myotonia in goats”. InNew Developments in Electromyographys and Clinical Neurophysiology, Ed. J. E. Desmedt, pp. 492–495. Basel: S. Karger.
Gillis, J. M. and M. Maes. 1973. “Is the Calcium pump involved in Thomson myotonia?” InNew Developments in Electromyography and Clinical Neurophysiology, Ed. J. E. Desmedt, pp. 492–495. Basel: S. Karger.
Gruener, R. 1967. “Caffeine contractures in sarcolemma-free muscle fibres”.J. Physiol.,191, 106–108.
Hodgkin, A. L. and A. F. Huxley. 1952. “A quantitative description of membrane current and its application to conduction and excitation in nerve”.J. Physiol.,117, 500–544.
Howell, G. N. 1969. “A lesion of the transverse tubules of skeletal muscle”.J. Physiol.,201, 515–533.
Hutter, I. F. and D. Noble. 1960. “The chloride conductance of frog skeletal muscle”.J. Physiol.,151, 89–102.
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Radu, H., Da Ronch, A. & Caldesi-Valeri, V. Calcium and myotonia: A mathematical model. Bltn Mathcal Biology 39, 577–585 (1977). https://doi.org/10.1007/BF02461203
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DOI: https://doi.org/10.1007/BF02461203