Abstract
The mean first passage time for free diffusion can be derived directly by solving a simple analogue steady state problem. In this problem the diffusion starting region is considered as a time independent source of diffusing particles and the diffusion target assumes the behaviour of a perfectly absorbing sink. It is shown here that the transit time between the source and the sink, which in this particular problem is equal to the ratio between the holdup of the system and the total flux, is identical to the Brownian movement concept of the mean first passage time for free diffusion. This established identity considerably facilitates the derivation and investigation of the timing of diffusion in complicated structures such as those commonly found in living organisms.
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Hardt, S.L. The diffusion transit time; A simple derivation. Bltn Mathcal Biology 43, 89–99 (1981). https://doi.org/10.1007/BF02460942
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DOI: https://doi.org/10.1007/BF02460942