Skip to main content
SpringerLink
Log in

Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin

  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Summary

We have developed two rodent models of diet-induced magnesium-deficiency in which histologically defined cardiac lesions can be induced within two to three weeks. During the development of these lesions, the magnesium-deficient animals exhibit circulating cytokine levels which are indicative of a generalized inflammatory state. Dramatic elevations of the macrophage-derived cytokines, IL-1, IL-6, and TNF-α together with signigicantly elevated levels of the endothelial cell-derived cytokine, endothelin, were detected in the plasma of these animals. We believe that the pathophysiological effects caused by the action of these cytokines may play a role in the promotion of cardiovascular pathology associated with magnesium deficiency.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aggarwal BB, Kohr WJ: Human tumor necrosis factor: Methods Enzymol 116: 448–456, 1985

    PubMed  CAS  Google Scholar 

  2. Ahmad A, Bloom S: Sodium pump and calcium channel modulation of Mg-deficiency cardiomyopathy. Am J Cardiovasc Pathol 2: 277–283, 1989

    PubMed  CAS  Google Scholar 

  3. Billingham MEJ: Cytokines as inflammatory mediators. Brit Med Bull 43: 350–370, 1987

    PubMed  CAS  Google Scholar 

  4. Bloom S: Magnesium deficiency cardiomyopathies. Amer J Cardiovasc Pathol 2: 7–17, 1988

    CAS  Google Scholar 

  5. Cavero PG, Miller WL, Heublein DM, Margulies KB, Burnett JC Jr: Endothelin in experimental congestive heart failure in the anesthetized dog. Am J Physiol 259: F312-F317, 1990

    PubMed  CAS  Google Scholar 

  6. Cernacek P, Stewart DJ: Immunoreactive endothelin in human plasma: marked elevations in patients in cardiogenic shock. Biochem Biophys Res Commun 161: 562–567, 1989

    Article  PubMed  CAS  Google Scholar 

  7. Clemens MJ, Morris AG, Gearing AJH: Lymphokines and interferons: A practical approach. IRL Press, Washington DC, 1987

    Google Scholar 

  8. Dubey A, Solomon R: Magnesium, myocardial ischemia and arrhythmias. Drugs 37: 1–7, 1989

    Article  PubMed  CAS  Google Scholar 

  9. Dubin D, Pratt RE, Cooke JP, Dzau VJ: Endothelin, apotent vasoconstrictor, is a vascular smooth muscle mitogen. J Vasc Med Biol 1: 150–154, 1989

    Google Scholar 

  10. Freedman AM, Atrakchi AH, Cassiday MM, Weglicki WB: Magnesium deficiency-induced cardiomyopathy: Protection by vitamin E. Biochem Biophys Res Comm 170: 1102–1106, 1990

    Article  PubMed  CAS  Google Scholar 

  11. Freedman AM, Cassidy MM, Weglicki WB: Captopril protects against myocardial injury induced by magnesium deficiency. Hypertension 18: 142–147, 1991

    PubMed  CAS  Google Scholar 

  12. Gehman LO, Robb RJ: An ELISA-based assay for quantitation of human IL-2. J Immunol Methods 74: 39–47, 1984

    Article  PubMed  CAS  Google Scholar 

  13. King AJ, Pfeffer JM, Pfeffer MA, Brenner BM: Systemic hemodynamic effects of endothelin in rats. Am J Physiol 258: H787-H792, 1990

    PubMed  CAS  Google Scholar 

  14. Lerman A, Click RL, Narr BJ, Weisner RH, Krom RAF, Textor SC, Burnett JC: Elevation of plasma endothelin associated with systemic hypertension in humans following orthotopic liver transplantation. Transplant 51: 646–650, 1991

    CAS  Google Scholar 

  15. Lerman A, Hildebrand FL, Margulies KB, O'Murchu B, Perrella MA, Heublein DM, Schwab TR, Burnett JC: Endothelin: A new cardiovascular regulatory peptide. Mayo Clin Proc 68: 1441–1455, 1990

    Google Scholar 

  16. Margulies KB, Hildebrand FL, Lerman A, Perrellam MA, Burnett JC: Increased endothelin in experimental heart failure. Circulation 82: 2226–2230, 1990

    PubMed  CAS  Google Scholar 

  17. Miyauchi T, Yanagisawa M, Tomizawa T, Sugishata Y, Suzuki N, Fujino M, Ajisaka P, Goto K, Masaki T: Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction. Lancet 2: 53–54, 1989

    Article  PubMed  CAS  Google Scholar 

  18. Nathan CF: Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J Clin Invest 80: 1550–1560, 1987

    Article  PubMed  CAS  Google Scholar 

  19. Seelig MS: Cardiovascular consequences of magnesium deficiency and loss. Amer J Cardiol 63: 4–21, 1989

    Article  Google Scholar 

  20. Underwood R, Chan DP, Burnett JC: Endothelin: An endothelium-derived vasoconstrictor peptide and its role in congestive heart failure. Heart Failure, April/May: 50–58, 1991

    Google Scholar 

  21. Watanabe T, Suzuki N, Shimamoto N, Fujino M, Imada A: Endothelin in myocardial infarction. Nature (London) 344: 114, 1990

    Article  CAS  Google Scholar 

  22. Whicher JT, Evans SW: Cytokines in disease. Clin Chem 36: 1269–1281, 1990

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, The George Washington University Medical Center, 20037, Washington DC, USA

    William B. Weglicki, Terry M. Phillips, Anthony M. Freedman, Marie M. Cassidy & Benjamin F. Dickens

  2. Department of Physiology, The George Washington University Medical Center, Room 402, Ross Hall, 2300 Eye Street NW, 20037, Washington DC, USA

    William B. Weglicki, Terry M. Phillips, Anthony M. Freedman, Marie M. Cassidy & Benjamin F. Dickens

Authors
  1. William B. Weglicki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Terry M. Phillips
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anthony M. Freedman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Marie M. Cassidy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Benjamin F. Dickens
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weglicki, W.B., Phillips, T.M., Freedman, A.M. et al. Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin. Mol Cell Biochem 110, 169–173 (1992). https://doi.org/10.1007/BF02454195

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02454195

Key words

Search

Navigation