Ischemic colitis during interferon-alpha treatment for chronic active hepatitis C
Received: 31 July 1995 Accepted: 24 November 1995 DOI:
Cite this article as: Tada, H., Saitoh, S., Nakagawa, Y. et al. J Gastroenterol (1996) 31: 582. doi:10.1007/BF02355061 Abstract
Between 1991 and 1994, at Hoshigaoka Koseinenkin Hospital, we treated 280 patients with chronic hepatitis C with interferon (IFN), and ischemic colitis occurred in two patients (0.7%) during the treatment. Melena appeared in case 1 in the 2nd month after the initiation of IFN-alpha treatment, and in case 2 in the 6th month. In both patients, longitudinal ulcerations in the descending colon were revealed by urgent colonoscopy, and these resolved within 2 weeks after discontinuation of the IFN treatment. It appears that ischemic colitis was associated with the IFN treatment, suggesting that attention should be paid to this possible complication.
Key words interferon chronic hepatitis C side effect ischemic colitis References
Bisceglie AM, Martin P, Kassianidies C, et al. Recombinant interferon alpha therapy for chronic hepatitis C. N Engl J Med 1989;321:1506–1510.
Roonnblom LE, Alm GV, Ooberg K. Autoimmune phenomena in patients with malignant carcinoid tumors during interferon-alpha treatment. Ann Intern Med 1991;115(3):178–183.
Scultz M, Muller R, Von zur Muhlen A, et al. Induction of hyperthyroidism by interferon-alpha-2b. Lancet 1989;I:1452.
Guyer DR, Tiedeman J, Yannuzi LA, et al. Interferon-associated retinopathy. Arch Opthalmol 1993;11:350–353.
Kamitsukasa H, Ohtake M, Kawashima H, et al. Two cases of interstitial pneumonia induced by interferon therapy for chronic aggressive hepatitis, type C. Acta Hepatol Jpn 1993;34:478–483.
Sonnenblick M, Rosin A. Cardiotoxicity of interferon. Chest 1991;99:557–561.
Mitoro A, Yoshikawa M, Yamamoto K, et al. Exacerbation of ulcerative colitis during alpha-interferon therapy for chronic hepatitis C. Intern Med 1993;32:327–331.
Pecorari P. Ulcerative colitis in hairy cell leukemia. A case report. Recent Prog Med 1991;82:269–271.
Sparano JA, Dutcher JP, Kaleya R, et al. Colonic ischemia complicating immunotherapy with interleukin-2 and interferon-alpha. Cancer 1991;68:1538–1544.
Boley SJ, Schwartz S, Lash J, et al. Reversible vascular occlusion of the colon. Surg Gynecol Obstet 1963;116:53–60.
Marston A, Phelis MT, Thomas ML, et al. Ischaemic colitis. Gut 1966;7:1–15.
Muto T, Kamitani J, Sawada T, et al. Ischemic colitis with special reference to colonoscopic and histological findings. Stomach and Intestine 1981;16:267–274.
Matolo NM, Albo DA. Gastrointestinal complications of collagen vascular diseases. Am J Surg 1971;122:678–682.
Kistin MG, Kaplan MM, Harrington JT. Diffuse ischemic colitis associated with systemic lupus erythematosus—response to subtotal colectomy. Gastroenterology 1978;75:1147–1151.
Reissman P, Weiss EG, Teoh TA, et al. Gangrenous ischemic colitis of the rectum: A rare complication of systemic lupus erythematosus. Am J Gastroenterol 1994;89:2234–2236.
Reid TJ, Lombard FA, Redmond J, et al. Digital vasculitis associated with interferon therapy. Am J Med 1992;92:702–703.
Vaddi K, Nicolini FA, Mehta P, et al. Increased secretion of tumor necrosis factor-alfa and interferon-gamma by mononuclear leukocytes in patients with ischemic heart disease. Circulation 1994;90:694–699.