Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: An ultrasonographic study
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An ultrasonographic study of ten healthy volunteers was carried out to evaluate the effect of cisapride on gastric antral emptying. More than 1 week after the measurement of the baseline emptying rate, cisapride was given at a single oral dose of 5 mg 30 minutes before intake of a balanced liquid test meal (5 ml/kg body weight). To determine the time to half emptying (T1/2), an exponential curve was extrapolated for the elimination phase of the gastroantral sagittal cross-sectional area plotted against time. The T1/2 was reduced by 18.5% after cisapride, from 62.6±4.3 to 51.0±4.4 min (P=0.0284). We conclude that a single oral dose of 5mg of cisapride significantly accelerates the gastric antral emptying rate in healthy humans.
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- Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: An ultrasonographic study
Journal of Gastroenterology
Volume 31, Issue 3 , pp 323-328
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- exponential curve
- gastric antral emptying
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- Author Affiliations
- 1. First Department of Surgery, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812-82, Fukuoka, Japan
- 2. Department of Medical Informatics, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812-82, Fukuoka, Japan