Adenosquamous carcinoma of the pancreas
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
A 58-year-old Japanese man was admitted complaining of abdominal pain. An abdominal computed tomography examination demonstrated a tumor in the head of the pancreas and multiple calcifications. A laparotomy was performed and the tumor was removed by Whipple's operation. Histologically, the neoplasm that invaded the duodenal wall and the papilla of Vater was composed of nests of malignant squamous cells with intercellular bridges and showed the formation of keratinized pearls with a small area of concurrently neoplastic glandular and squamous elements. On the basis of these features, the diagnosis of adenosquamous carcinoma of the pancreas was made. The patient died 18 months after the operation. The neoplastic behavior of this rare primary pancreatic carcinoma is similar to that of duct cell carcinoma as well as pure squamous cell carcinoma of the pancreas. As the pancreas can be the target of metastases of squamous carcinomas from other organs it is wise to be aware of this rare entity.
Rosaid J. Pancreas and periampullary region. In: Stamathis G (ed) Ackerman's surgical pathology. St Louis: C.V. Mosby 1989;757–788.
Sommers SC, Meissner WA. Unusual carcinomas of the pancreas. Arch Pathol 1954;58:101–111.
Kishi K, Hirota T, Nakamura K, et al. Carcinoma of the pancreas: A review of 94 autopsy cases. Jpn J Clin Oncol 1980;10: 273–280.
Ishikawa O, Matsui Y, Aoki I, et al. Adenosquamous carcinoma of the pancreas: A clinicopathologic study and report of three cases. Cancer 1980;46:1192–1196.PubMed
Tungekar MF, Gatter KC, Al-Adnani MS. Immunohistochemistry of cytokeratin proteins in squamous and transitional cell lesions of the urinary tract. J Clin Pathol 1988;41:1288–1296.PubMed
Kamino H, Huang SJ, Fu YS. Keratin and involucrin immunohistochemistry of nasopharyngeal carcinoma. Cancer 1988;61: 1142–1148.PubMed
Baylor SM, Berg JW. Cross-classification and survival characteristics of 5000 cases of cancer of the pancreas. J Surg Oncol 1973;5:335–358.PubMed
Cihak RW, Kawashima T, Steer A. Adenoacanthoma (adenosquamous carcinoma) of the pancreas. Cancer 1972; 29:1133–1140.PubMed
Cubilla AL, Fitzgerald PJ. Morphological patterns of primary nonendocrine human pancreas carcinoma. Cancer Res 1975; 35:2234–2248.PubMed
Morohoshi T, Held G, Klöppel G. Exocrine pancreatic tumours and their histological classification. A study based on 167 autopsy and 97 surgical cases. Histopathology 1983;7:645–661.PubMed
Kissane JM. Carcinoma of the exocrine pancreas: Pathologic aspects. J Surg Oncol 1975;7:167–174.PubMed
Tomiyama T, Ueno N, Fukuda M, et al. Two cases of adenosquamous carcinoma of the pancreas (in Japanese with English abstract). Suizou (Pancreas) 1994;9:234–239.
Ikei S, Katafuchi S, Beppu T, et al. A case of adenosquamous carcinoma of the pancreas (in Japanese with English abstract). Suizou (Pancreas) 1993;8:545–551.
Sato K, Suzuki R, Kurosu Y, et al. Squamous cell carcinoma of the pancreas: A case report. Nihon Univ J Med 1986;28:419–426.
Klöppel G, Fitzgerald PJ. Pathology of nonendocrine pancreatic tumors. In: Go VLW (ed) The exocrine pancreas: Biology, pathobiology, and diseases. New York: Raven, 1986;649–674.
Cubilla AL, Fitzgerald PJ. Morphological lesions associated with human primary invasive nonendocrine pancreas cancer. Cancer Res 1976;36:2690–2698.PubMed
Chen J, Baithun SI. Morphological study of 391 cases of exocrine pancreatic tumours with special reference to the classification of exocrine pancreatic carcinoma. J Pathol 1985;146:17–29.PubMed
Hartsock RJ, Fisher E. Cancer in situ in pancreatic squamous metaplasia. Arch Surg 1971;82:56–60.
- Adenosquamous carcinoma of the pancreas
Journal of Gastroenterology
Volume 30, Issue 6 , pp 798-802
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- adenosquamous carcinoma
- mucoepidermoid carcinoma
- Industry Sectors
- Author Affiliations
- 1. Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852, Nagasaki, Japan
- 2. Department of Internal Medicine, Hokusho Central Hospital, 299 Akasaka-men, Emukae-cho, Kitamatsuura-gun, 859-61, Nagasaki, Japan
- 3. Department of Pathology, Saga Medical School, 5-1-1 Nabeshima, 849, Saga, Japan