Journal of Neural Transmission - Parkinson's Disease and Dementia Section

, Volume 7, Issue 2, pp 115–121

NADPH-diaphorase/nitric oxide synthase containing neurons in normal and Parkinson's disease putamen


  • R. Böckelmann
    • Institute of Medical Neurobiology, Medical FacultyUniversity of Magdeburg
  • G. Wolf
    • Institute of Medical Neurobiology, Medical FacultyUniversity of Magdeburg
  • G. Ransmayr
    • Department of NeurologyUniversity of Innsbruck
  • P. Riederer
    • Department of PsychiatryUniversity of Würzburg
Full Papers

DOI: 10.1007/BF02260966

Cite this article as:
Böckelmann, R., Wolf, G., Ransmayr, G. et al. J Neural Transm Gen Sect (1994) 7: 115. doi:10.1007/BF02260966


Nitric oxide (NO) is thought to be involved in neurodegenerative processes. Concerning Parkinson's disease (PD) it remains to be elucidated, if NO contributes to pathological alterations in the striatum. The present study evaluates the post-mortem putamen of PD patients and control subjects for distribution patterns of NO-synthase containing neurons, using the NADPH-diaphorase technique. The ratio of positively stained neurons and the total number of cells (control: 1,120±69 per mm2, n=5; PD: 575±164mm2, n=5) shows striking differences between controls and PD patients. Our findings give reason to conclude that NADPH-diaphorase positive structures may have pathogenetic importance in degenerative processes in PD putamen.


Parkinson's diseaseputamenNADPH-diaphorasenitric oxide synthase

Copyright information

© Springer-Verlag 1994