, Volume 102, Issue 1, pp 73–75

Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder


  • Anat Biegon
    • Weizman Institute of Science
  • Nir Essar
    • Abarbenael Mental Health Center
  • Malka Israeli
    • Weizman Institute of Science
  • Avner Elizur
    • Abarbenael Mental Health Center
  • Shlomo Bruch
    • Abarbenael Mental Health Center
  • Aliezer A. Bar-Nathan
    • Department of PsychiatryTel Aviv Medical Center
Original Investigations

DOI: 10.1007/BF02245747

Cite this article as:
Biegon, A., Essar, N., Israeli, M. et al. Psychopharmacology (1990) 102: 73. doi:10.1007/BF02245747


Serotonin receptors of the 5-HT2 type were studied on platelet membranes from 15 patients suffering from major depression. Receptor binding and clinical state (assessed by the Hamilton and Beck rating scales) were examined in a drug free state upon admission and after 1 and 3 weeks of treatment with the antidepressant maprotiline (MPT). 5-HT2 receptor binding changed in correlation with changes in the clinical state of the patients as judged by the rating scales. Since most patients showed a clinical improvement, the patients as a group exhibited a significant decrease in binding concomitant with a drop in depression scores. However, in those patients in whom there was no clinical change or an increase in depression scores, 5-HT2 receptor binding did not change or increased, respectively, thus resulting in a significant correlation between clinical changes and changes in binding. These results support the use of 5-HT2 receptors on platelets in evaluating depression and its treatment.

Key words

SerotoninPlateletsDepression5-HT2 receptorsMaprotiline

Copyright information

© Springer-Verlag 1990