Psychopharmacology

, Volume 104, Issue 4, pp 413–424

Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology

Authors

  • Grazyna Gora-Maslak
    • Center for Developmental and Health GeneticsPennsylvania State University
  • Gerald E. McClearn
    • Center for Developmental and Health GeneticsPennsylvania State University
  • John C. Crabbe
    • VA Medical Center and Departments of Medical Psychology and PharmacologyOregon Health Sciences University
  • Tamara J. Phillips
    • VA Medical Center and Departments of Medical Psychology and PharmacologyOregon Health Sciences University
  • John K. Belknap
    • VA Medical Center and Departments of Medical Psychology and PharmacologyOregon Health Sciences University
  • Robert Plomin
    • Center for Developmental and Health GeneticsPennsylvania State University
Review

DOI: 10.1007/BF02245643

Cite this article as:
Gora-Maslak, G., McClearn, G.E., Crabbe, J.C. et al. Psychopharmacology (1991) 104: 413. doi:10.1007/BF02245643

Abstract

Unlike simple Mendelian characteristics, individual differences in complex quantitative phenotypes studied in psychopharmacology are generally distributed continuously and are likely to be influenced by many genes. Recombinant inbred (RI) strains are valuable not only for their traditional use of detecting major gene segregation and linkage but also for identifying associations between quantitative traits and quantitative trait loci (QTL) that account for relatively small amounts of variation in phenotypes as well as loci that account for greater amounts of variation. When applied to published data on genetic markers and on amphetamine, alcohol, and morphine responses in BXD RI strains (RI strains developed from the cross between C57BL/6J and DBA/2J progenitor inbred strains), the RI QTL approach identified several significant associations beyond known major gene effects. Together, significant associations explain more than half of the genetic variance for these measures. The RI QTL approach is especially valuable for investigating the QTL underpinnings of genetic correlations among measures. It is recommended that psychopharmacogenetic research focus on the BXD RI strains. The cumulative and integrative nature of such a program of research is the major benefit of the RI QTL association approach for molecular genetic analysis of psychopharmacological processes, their physiological infrastructure, and their interface with other behavioral and biological systems.

Key words

Quantitative traitsQuantitative trait lociRecombinant inbred strainsBXDAmphetamineAlcoholMorphineAssociation
Download to read the full article text

Copyright information

© Springer-Verlag 1991