Primary biliary cirrhosis induced by interferon-α therapy for hepatitis C virus infection
- Cite this article as:
- D'Amico, E., Paroli, M., Fratelli, V. et al. Digest Dis Sci (1995) 40: 2113. doi:10.1007/BF02208992
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Interferon-α is known to exacerbate and in some cases induce a variety of autoimmune disorders. In this report we describe the onset of primary biliary cirrhosis in a 55-year-old woman without evidence of preexisting autoimmune diseases receiving recombinant interferon-α2a for chronic active hepatitis C. Shortly after discontinuating interferon therapy, alkaline phosphatase levels started to rise up to three times the normal range. Anti-mithocondrial antibodies were found to be positive at a high titer, and liver biopsy showed a picture of chronic active hepatitis along with primary biliary cirrhosis features (overlap syndrome). Primary biliary cirrhosis should be considered in the differential diagnosis in any patient treated with interferon-α with unexplained elevation of serum alkaline phosphatase.