Original Paper

European Archives of Psychiatry and Clinical Neuroscience

, Volume 246, Issue 4, pp 182-184

Lack of association between schizophrenia and the apolipoprotein E ε4 allele

  • E. JönssonAffiliated withDepartment of Clinical Neuroscience, Psychiatry Section, Karolinska Institute
  • , G. SedvallAffiliated withDepartment of Clinical Neuroscience, Psychiatry Section, Karolinska Institute
  • , L. LannfeltAffiliated withDepartment of Geriatric Medicine, Huddinge Hospital
  • , B. EngvallAffiliated withDepartment of Geriatric Medicine, Huddinge Hospital

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Abstract

The association between the ε4 allele of the apolipoprotein E (APOE) gene and Alzheimer's disease (AD) has been reported. In order to examine if the ε4 allele may play a role also in schizophrenia, another mental disorder, patients (n=87) and control subjects (n=57) were genotyped for APOE. No significant difference was found between the groups. The data indicate that the APOE gene is not of major importance for the genesis of schizophrenia.

Key words

Schizophrenia Apolipoprotein E Association study Psychiatric genetics Alzheimer's disease