Lack of association between schizophrenia and the apolipoprotein E ε4 allele

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The association between the ε4 allele of the apolipoprotein E (APOE) gene and Alzheimer's disease (AD) has been reported. In order to examine if the ε4 allele may play a role also in schizophrenia, another mental disorder, patients (n=87) and control subjects (n=57) were genotyped for APOE. No significant difference was found between the groups. The data indicate that the APOE gene is not of major importance for the genesis of schizophrenia.