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Crohn's disease and vitamin B12 metabolism

  • Intestinal Disorders, Inflammatory Bowel Disease, Immunology, And Microbiology
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Abstract

The concentrations of vitamin B12, its analogs, and the haptocorrin and transcobalamin carriers in 21 patients suffering from Crohn's disease and a group of controls (20 adults) were measured. There were no significant differences in the mean values for vitamin B12, total corrinoids (vitamin B12 + analogs), or vitamin B12 or total corrinoids bound to haptocorrin or transcobalamin of the Crohn's and control patients. There was a significant increase in the binding capacity of transcobalamin in the Crohn's patients compared to the controls (P<0.001), but there was no difference in the binding capacities of haptocorrin. The serum concentrations of the markers of vitamin B12 status, homocysteine and methylmalonic acid, showed an increase (P<0.01) in homocysteine in the Crohn's disease patients, but no change in methylmalonic acid. As the hyperhomocysteinemia was associated with normal folate concentrations, there may have been a defect in the activation of the enzyme due to altered intracellular vitamin B12 status.

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Authors and Affiliations

  1. Biochemistry Laboratory, C.H.R., 54000, Nancy, France

    Daniel Lambert PhD, Samira Benhayoun MS, Charles Adjalla MS, Marie-Andree Gélot PD, Pascal Renkes MD, Franck Felden PD, MS, Philippe Gérard Engineer, Francine Belleville PD, Pierre Gaucher MD, Jean-Louis Guéant MD, PhD & Jean-Pierre Nicolas MD

  2. Hepato-gastroenterology, C.H.R.U., 54500, Vandoeuvre, France

    Daniel Lambert PhD, Samira Benhayoun MS, Charles Adjalla MS, Marie-Andree Gélot PD, Pascal Renkes MD, Franck Felden PD, MS, Philippe Gérard Engineer, Francine Belleville PD, Pierre Gaucher MD, Jean-Louis Guéant MD, PhD & Jean-Pierre Nicolas MD

  3. INSERM Unit 308, Faculté de Médecine, B.P. 184, 54505, Vandoeuvre Cédex, France

    Daniel Lambert PhD, Samira Benhayoun MS, Charles Adjalla MS, Marie-Andree Gélot PD, Pascal Renkes MD, Franck Felden PD, MS, Philippe Gérard Engineer, Francine Belleville PD, Pierre Gaucher MD, Jean-Louis Guéant MD, PhD & Jean-Pierre Nicolas MD

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  1. Daniel Lambert PhD
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  2. Samira Benhayoun MS
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  7. Philippe Gérard Engineer
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  8. Francine Belleville PD
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  10. Jean-Louis Guéant MD, PhD
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  11. Jean-Pierre Nicolas MD
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Lambert, D., Benhayoun, S., Adjalla, C. et al. Crohn's disease and vitamin B12 metabolism. Digest Dis Sci 41, 1417–1422 (1996). https://doi.org/10.1007/BF02088567

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  • DOI: https://doi.org/10.1007/BF02088567

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