Digestive Diseases and Sciences

, Volume 40, Issue 6, pp 1252–1256

Small bowel bacterial overgrowth in patients with alcoholic cirrhosis

Authors

  • F. Casafont Morencos
    • From the Department of GastroenterologyHospital Universitario Marqués de Valdecilla
  • G. de las Heras Castano
    • From the Department of GastroenterologyHospital Universitario Marqués de Valdecilla
  • L. Martín Ramos
    • From the Department of GastroenterologyHospital Universitario Marqués de Valdecilla
  • Maria J. López Arias
    • From the Department of GastroenterologyHospital Universitario Marqués de Valdecilla
  • F. Ledesma
    • From the Department of GastroenterologyHospital Universitario Marqués de Valdecilla
  • F. Pons Romero
    • From the Department of GastroenterologyHospital Universitario Marqués de Valdecilla
Liver: Cirrhosis, Fibrosis, Portal Hypertension, And Transplantation

DOI: 10.1007/BF02065533

Cite this article as:
Casafont Morencos, F., de las Heras Castano, G., Martín Ramos, L. et al. Digest Dis Sci (1995) 40: 1252. doi:10.1007/BF02065533

Abstract

A total of 89 patients with alcoholic cirrhosis and 40 healthy subjects were included in a study to assess the prevalence of intestinal bacterial overgrowth and to analyze its relationship with the severity of liver dysfunction, presence of ascites, and development of spontaneous bacterial peritonitis (SBP). Bacterial overgrowth was measured by means of a breath test after ingestion of glucose. Intestinal bacterial overgrowth was documented in 27 (30.3%) of the 89 patients with alcoholic cirrhosis and in none of the healthy subjects. The prevalence of intestinal bacterial overgrowth was significantly higher in cirrhotics with ascites (37.1%) than in those with no evidence of ascites (5.3%) and among patients with Pugh-Child class C (48.3%) than in patients with class A (13.1%) or B (27%). Twelve (17.1%) of the 70 patients with ascites developed an episode of SBP. The prevalence of spontaneous bacterial peritonitis was significantly higher in patients who had intestinal bacterial overgrowth (30.7%) than in patients who did not (9.09%). We conclude that intestinal bacterial overgrowth occurs in approximately one third of patients with cirrhosis secondary to alcohol, particularly in patients with ascites and advanced liver dysfunction. Moreover, bacterial overgrowth may be a condition favoring infection of the ascitic fluid.

Key words

alcoholic liver cirrhosisintestinal bacterial overgrowthbacterial translocationascitesspontaneous bacterial peritonitis

Copyright information

© Plenum Publishing Corporation 1995