Digestive Diseases and Sciences

, Volume 40, Issue 4, pp 819–827

Visceral perception in irritable bowel syndrome

Rectal and gastric responses to distension and serotonin type 3 antagonism

Authors

  • Jaime Zighelboim
    • From the Division of Gastroenterology and Internal Medicine, Department of Health Sciences ResearchMayo Clinic and Foundation
  • Nicholas J. Talley
    • From the Division of Gastroenterology and Internal Medicine, Department of Health Sciences ResearchMayo Clinic and Foundation
  • Sidney F. Phillips
    • From the Division of Gastroenterology and Internal Medicine, Department of Health Sciences ResearchMayo Clinic and Foundation
  • William S. Harmsen
    • From the Division of Gastroenterology and Internal Medicine, Department of Health Sciences ResearchMayo Clinic and Foundation
  • Alan R. Zinsmeister
    • From the Division of Gastroenterology and Internal Medicine, Department of Health Sciences ResearchMayo Clinic and Foundation
Intestinal Disorders, Inflammatory Bowel Disease, Immunology And Microbiology

DOI: 10.1007/BF02064986

Cite this article as:
Zighelboim, J., Talley, N.J., Phillips, S.F. et al. Digest Dis Sci (1995) 40: 819. doi:10.1007/BF02064986

Abstract

We wished to determine if visceral perception in the rectum and stomach is altered in patients with irritable bowel syndrome and to evaluate the effects on visceral sensation of 5-HT3 receptor blockade. Twelve community patients with diarrhea-predominant irritable bowel syndrome and 10 healthy controls were studied in a double-blind, randomized, placebo-controlled study. Using two barostats, the stomach and rectum were distended, with pressure increments of 4 mm Hg, from 10 to 26 mm Hg; visceral perception was measured on an ordinal scale of 0–10. Personality traits were measured using standard psychological methods, and somatic pain was evaluated by immersion of the nondominant hand in cold water. The effect of 5-HT3 antagonism was tested with a single intravenous dose of ondansetron at 0.15 mg/kg. Gastric perception was higher in irritable bowel syndrome, but rectal distension was perceived similarly in irritable bowel syndrome and controls. Pain tolerance to cold water was also similar in irritable bowel syndrome and controls. Ondansetron induced rectal relaxation and increased rectal compliance but did not significantly alter gastric compliance or visceral perception. Psychological test scores were similar in patients and controls. We conclude that in this group of psychologically normal patients with irritable bowel syndrome, who were not chronic health-care seekers, visceral perception was normal. Ondansetron did not alter gut perception in health or in irritable bowel syndrome.

Key words

gastric and rectal distensionirritable bowel syndromeondansetron

Copyright information

© Plenum Publishing Corporation 1995