Skip to main content
Log in

The dental amalgam issue. A review

  • Reviews
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Using an interdisciplinary approach, the current position in the dental amalgam controversy and the potential impact of amalgam mercury on human health are reviewed. Aspects of materials science, corrosion, mercury exposure, toxicology, neurology and immunology are included.

New data on mercury exposure from corroded amalgam fillings in vivo are presented. The exposure can reach levels considerably over known threshold limit values. Also, measurements of mercury absorption from intraoral air are presented. The vital importance of avoiding a galvanic amalgam-gold coupling is emphasized. The symptomatology of a disabled patient, who recovered after amalgam removal, has been included.

It is concluded that discussion of the dental amalgam issue has suffered from the lack of an interdisciplinary approach. It would be wise to learn from the lesson of acrodynia, and consider amalgam mercury among other possible factors in neurological and immunological diseases of unclear etiology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literatur

  1. Abraham, J. E., Svare, C. W., and Frank, C. W., The effect of dental amalgam restorations on blood mercury levels. J. dent. Res.63 (1984) 71–73.

    Google Scholar 

  2. Adams, C. R., Ziegler, D. K., and Lin, J. T., Mercury intoxication simulating amyotrophic lateral sclerosis. JAMA250 (1983) 642–643.

    Google Scholar 

  3. Ahlqwist, M., Bengtsson, C., Furunes, B., Hollender, L., and Lapidus, L., Number of amalgam tooth fillings in relation to subjectively experienced symptoms. Commun. dent. oral Epidemiol.16 (1988) 227–231.

    Google Scholar 

  4. Ahlrot-Westerlund, B., Carlmark, B., Grönquist, S.-O., Johansson, E., Lindh, U., Theorell, H., and de Vahl, K., Altered distribution patterns of macro- and trace elements in human tissues of patients with decreased levels of blood selenium. Nutr. Res. Suppl.1 (1985) 442–450.

    Google Scholar 

  5. Baader, E. W., Quecksilbervergiftung, in: Handbuch der gesamten Arbeitsmedizin, vol. 2, pp. 158–176 (1961).

  6. Baader, E. W., and Holstein, E. (Eds), Das Quecksilber, seine Gewinnung, technische Verwendung und Giftwirkung, R. Schoetz Verl., Berlin 1933.

    Google Scholar 

  7. Baasch, E., Theoretische Ueberlegungen zur Aetiologie der Sclerosis Multiplex. Die Multiple Sklerose eine Quecksilberallergie? Schw. Arch. Neurol. Neurochir. Psychiat.98 (1966) 1–18.

    Google Scholar 

  8. Barber, T. E., Inorganic mercury intoxication reminiscent of amyotrophic lateral sclerosis. J. occup. Med.20 (1978) 667–669.

    Google Scholar 

  9. Berglund, A., Pohl, L., Olsson, S., and Bergman, M., Determination of the rate of release of intra-oral mercury vapor from amalgam. J. dent. Res.67 (1988) 1235–1242.

    Google Scholar 

  10. Bernaudin, J. F., Druet, E., Druet, P., and Masse, R., Inhalation or ingestion of organic or inorganic mercurials produces autoimmune disease in rats. Clin. Immunol. Immunopath.20 (1981) 129–135.

    Google Scholar 

  11. Bidstrup, P. L., Bonell, J. A., Harvey, D. G., and Locket, S., Chronic mercury poisoning in men repairing direct-current meters. Lancet2 (1951) 856–861.

    Google Scholar 

  12. Borinski, P., Die Herkunft des Quecksilbers in den menschlichen Ausscheidungen. Zahnärztl. Rundschau40 (1931) 223–230.

    Google Scholar 

  13. Boyd, M. A., and Richardson, A. S., Frequency of amalgam replacement in general dental practice. J. Can. dent. Ass.10 (1985) 763–766.

    Google Scholar 

  14. Brecht-Bergen, N., Korrosionsuntersuchungen an Zinn-Silber-Amalgamen. Zeitschr. Elektrochemie39 (1933) 927–935.

    Google Scholar 

  15. Brune, D., A model for recording mercury release from an amalgam surface. Biomaterials6 (1985) 357–359.

    Google Scholar 

  16. Brune, D., Metal release from dental biomaterials. Biomaterials7 (1986) 163–175.

    Google Scholar 

  17. Burgener, P., and Burgener, A., Erfahrungen über chronische Quecksilbervergiftungen. Schw. med. Wschr.8 (1952) 204–210.

    Google Scholar 

  18. Cantoni, O., Christie, N. T., Swann, A., Drath, D. B., and Costa, M., Mechanism of HgCl2 cytotoxicity in cultured mammalian cells. Molec. Pharmac.26 (1984) 360–368.

    Google Scholar 

  19. Chang, L. W., and Hartmann, H. A., Blood-brain barrier dysfunction in experimental mercury intoxication. Acta neuropath.21 (1972) 179–184.

    Google Scholar 

  20. Chavez, E., and Holguin, J. A., Mitochondrial calcium release as induced by Hg2+. J. biol. Chem.263 (1988) 3582–3587.

    Google Scholar 

  21. Cherian, M. G., Hursh, J. B., Clarkson, T. W., and Allen, J., Radioactive mercury distribution in biological fluids and excretion in human subjects after inhalation of mercury vapor. Arch. envir. Hlth33 (1978) 109–114.

    Google Scholar 

  22. Clarkson, T. W., The pharmacology of mercury compounds. A. Rev. Pharmac.12 (1972) 375–406.

    Google Scholar 

  23. Contrino, J., Marucha, P., Ribaudo, R., Ference, R., Bigazzi, P. E., and Kreutzer, D. L., Effects of mercury on human polymorphonuclear leukocyte function in vitro. Am. J. Path.132 (1988) 110–118.

    Google Scholar 

  24. Cremer, F., (Ed.), Die Fabrikation der Silber- und Quecksilber-Spiegel. Hartlebens Verlag, Wien/Leipzig 1904.

    Google Scholar 

  25. Daunderer, M., Amalgam. Klin. Toxikologie46 (1989) 1–54.

    Google Scholar 

  26. DeLong, R., Sakaguchi, R. L., Douglas, W. H., and Pintado, M. R., The wear of dental amalgam in an artificial mouth: a clinical correlation. Dent. Mater.1 (1985) 238–242.

    Google Scholar 

  27. Dencker, I., and Schütz, A., Kvicksilverinnehållet i kosten. Läkartidn.68 (1971) 4031–4033.

    Google Scholar 

  28. Dieter, M. P., Luster, M. I., Boorman, G. A., Jameson, C. W., Dean, J. H., and Cox, J. W., Immunological and biochemical responses in mice treated with mercuric chloride. Toxic. appl. Pharmac.68 (1983) 218.

    Google Scholar 

  29. Djerassi, E., and Berova, N., The possibilities of allergic reactions from silver amalgam restorations. Int. dent. J.19 (1969) 481–488.

    Google Scholar 

  30. Domanska-Janik, K., and Bourre, J. M., Effect of mercury on rabbit myelin CNP-ase in vitro. Neurotoxicology8 (1987) 23–32.

    Google Scholar 

  31. Dörffer, U., Anorexia hydrargyra. Kasuistik aus der Praxis. Monatschr. Kinderheilk.137 (1989) 472.

    Google Scholar 

  32. Druet, P., Hirsch, F., Sapin, C., Druet, E., and Bellon, B., Immune dysregulation and autoimmunity induced by toxic agents. Transpl. Proc.14 (1982) 482–484.

    Google Scholar 

  33. Eggleston, D. W., Effect of dental amalgam and nickel alloys on T-lymphocytes: preliminary report. J. Prosth. Dent.51 (1984) 617–623.

    Google Scholar 

  34. Eide, I., and Syversen, T. L. M., Uptake of elemental mercury and activity of catalase in rat, hamster, guinea-pig, normal and acatalasemic mice. Acta pharmac. toxic.51 (1982) 371–376.

    Google Scholar 

  35. Espevik, S., Dental Amalgam. A. Rev. Mater. Sci.7 (1977) 55–72.

    Google Scholar 

  36. Espevik, S., In vitro corrosion of dental amalgams with different Cu content. Scand. J. dent. Res.85 (1977) 631–636.

    Google Scholar 

  37. Espevik, S., and Mjör, I. A., Degradation of amalgam restorations in vivo, in: Corrosion and Degradation of Implant Materials, pp. 316–327. ASTM STP 684 (1979).

  38. Fanconi, G., Botsztejn, A., and Schenker, P., Ueberempfindlichkeitsreaktionen auf Quecksilbermedikation im Kindesalter mit besonderer Berücksichtigung der Calomelkrankheit. Helv. paediatr. Acta2, suppl. 4 (1947) 3–46.

    Google Scholar 

  39. Fleischmann, P., Zur Frage der Gefährlichkeit kleinster Quecksilbermengen. Zschr. angew. Chem.41 (1928) 66–70.

    Google Scholar 

  40. Fraunhofer, J. A., and Staheli, P. J., Gold-amalgam galvanic cells. Br. dent. J.132 (1972) 357–362.

    Google Scholar 

  41. Fredin, B., Studies on the mercury release from dental amalgam fillings. Swed. J. Biol. Med.3 (1988) 8–15.

    Google Scholar 

  42. Friberg, L., and Vostal, J., (Eds), Mercury in the Environment, CRC Press, Cleveland 1972.

    Google Scholar 

  43. Frykholm, K. O., Mercury from dental amalgam. Its toxic and allergic effects and some comments on occupational hygiene. Acta odont. scand.15, suppl. 22 (1957) 1–108.

    Google Scholar 

  44. Gay, D. D., Cox, R. D., and Reinhardt, J. W., Chewing releases mercury from fillings. Lancet1 (1979) 985–986.

    Google Scholar 

  45. Gerstner, H. B., and Huff, J. E., Clinical toxicology of mercury. J. Toxic. envir. Hlth2 (1977) 491–526.

    Google Scholar 

  46. Gmelin's Handbuch der anorganischen Chemie, 34A, 2nd edn, Lief.

  47. Guthrow, C. E., Johnson, L. B., and Lawless, K. R., Corrosion of dental amalgam and its component phases. J. dent. Res.46 (1967) 1372–1381.

    Google Scholar 

  48. Hahn, L. J., Kloiber, R., Vimy, M. J., Takahashi, Y., and Lorscheider, F. L., Dental ‘silver’ tooth fillings: a source of mercury exposure revealed by whole-body image scan and tissue analysis FASEB J.3 (1989) 2641–2646.

    Google Scholar 

  49. Harndt, E., ergebnisse klinischer Untersuchungen zur Lösung der Amalgam-Quecksilberfrage. Dt. zahnärztl. Wschr.33 (1930) 564–575.

    Google Scholar 

  50. Hugoson, A., Results obtained from patients referred for the investigation of complaints related to oral galvanism. Swed. dent. J. 10 (1986) 15–28.

    Google Scholar 

  51. Hursh, J. B., Clarkson, T. W., Cherian, M. G., Vostal, J., and Mallie, R. V., Clearance of mercury (Hg-197, Hg-203) vapor inhaled by human subjects. Arch. envir. Hlth31 (1976) 302–309.

    Google Scholar 

  52. Hyams, B. L., and Ballon, H. C., Dissimilar metals in the mouth as a possible cause of otherwise unexplainable symptoms. Can. med. Ass. J. (1933) 488–491.

  53. Ingalls, T. H., Triggers for multiple sclerosis. Lancet2 (1986) 160.

    Google Scholar 

  54. Jontell, M., Haraldson, T., Persson, L.-O., and Öhman, S.-C., An oral and psychosocial examination of patients with presumed oral galvanism. Swed. dent. J.9 (1985) 175–185.

    Google Scholar 

  55. Jörgensen, K. D., Dental Amalgams (in danish) p. 8. Odontologisk Boghandels Forl. 1976.

  56. Jörgensen, K. D., The mechanism of marginal fracture of amalgam fillings. Acta odont. scand.23 (1965) 347–389.

    Google Scholar 

  57. Jörgensen, K. D., and Saito, T., Structure and corrosion of dental amalgams. Acta odont. scand.28 (1970) 129–142.

    Google Scholar 

  58. Kantarjian, A. D., A syndrome clinically resembling amyotrophic lateral sclerosis following chronic mercurialism. Neurology11 (1961) 639–644.

    Google Scholar 

  59. Klock, B., Blomgren, J., Ripa, U., and Andrup, B., Effekt av amalgamavlägsnande på patienter som misstänker att de lider eller har lidit av amalgamförgiftning. Tandläkartidn.81 (1989) 1297–1302.

    Google Scholar 

  60. Knappwost, A., Gura, E., Fuhrmann, D., and Enginalev, A., Abgabe von Quecksilberdampf aus Dentalamalgamen unter Mundbedingungen. Zahnärztl. Welt/Reform94 (1985) 131–139.

    Google Scholar 

  61. Knolle, G., and Günther, B., Beitrag zu der Ätiologiehypothese: Amalgam und Multiple Sklerose. Schw. Monatschr. Zahnheilk.77 (1967) 761–776.

    Google Scholar 

  62. Kozono, Y., Moore, B. K., Phillips, R. W., and Swartz, M. L., Dissolution of amalgam in saline solution. J. biomed. Mat. Res.16 (1982) 767–774.

    Google Scholar 

  63. Kröncke, A., Ott, K., Petschelt, A., Schaller, K.-H., Szecsi, M., and Valentin, H., Ueber die Quecksilberkonzentrationen in Blut und Urin von Personen mit und ohne Amalgamfüllungen. Dt. zahnärztl. Z.35 (1980) 803–808.

    Google Scholar 

  64. Kussmaul, A., (Ed.), Untersuchungen über den constitutionellen Mercurialismus und sein Verhältniss zur constitutionellen Syphilis. Würzburg, 1861.

  65. Lain, E., and Caughron, G. S., Electrogalvanic phenomena of the oral cavity caused by dissimilar metallic restorations. J. Am. dent. Ass.23 (1936) 1641–1652.

    Google Scholar 

  66. Lain, E., Schriever, W., and Caughron, G. S., Problem of electrogalvanism in the oral cavity caused by dissimilar dental metals. J. Am. dent. Ass.27 (1940) 1765–1772.

    Google Scholar 

  67. Lamm, O., and Pratt, H., Subclinical effects of exposure to inorganic mercury revealed by somatosensory-evoked potentials. Eur. Neurol.24 (1985) 237–243.

    Google Scholar 

  68. Lambrechts, P., Vuylsteke, M., Vanherle, G., and Davidson, C. L., Quantitative in vivo wear of posterior dental restorations, four-year result. J. dent. Res.62 (1985) 370, abstr. no. 1759.

    Google Scholar 

  69. Langworth, S., Elinder, C.-G., and Åkesson, A., Mercury exposure from dental fillings. I. Mercury concentrations in blood and urine. Swed. dent. J.12 (1988) 69–70.

    Google Scholar 

  70. Lavstedt, S., and Sundberg, H., Medicinska diagnoser och sjukdomssymtom relaterade till amalgamfyllningar, Tandläkartidn.81 (1989) 81–88.

    Google Scholar 

  71. Malmström, C., Cracking and cuspfractures in teeth with amalgam fillings. Tidskr. Landlaeger6 (1986) 65–68;8 (1988) 53–59.

    Google Scholar 

  72. Marek, M., Acceleration of corrosion of dental amalgams by abrasion. J. dent. Res.63 (1984) 1010–1013.

    Google Scholar 

  73. Marek, M., and Okabe, T., Corrosion behaviour of structural phases in high copper dental amalgams. J. biomed. Mat. Res.12 (1978) 857–866.

    Google Scholar 

  74. Marxkors, R., Korrosionserscheinungen an Amalgamfüllungen und deren Auswirkungen auf den menschlichen Organismus. Dt. Zahnärzteblatt24 (1970) 53–65.

    Google Scholar 

  75. Mateer, R. R., and Reitz, C. D., Corrosion of amalgam restorations. J. dent. Res.49 (1970) 399–407.

    Google Scholar 

  76. Mayer, R., and Diehl, W., Abgabe von Quecksilber aus Amalgamfüllungen in den Speichel, Dt. zahnärztl. Z.31 (1976) 855–859.

    Google Scholar 

  77. Maximum Allowable Concentrations of Mercury Compounds. Report of an International Committee. Arch. envir. Hlth19 (1969) 891-905.

    Google Scholar 

  78. Meeuwissen, R., Van Elteren, P., Eschen, S., and Mulder, J., Durability of amalgam restorations in premolars and molars in Dutch servicemen. Commun. dent. Hlth2 (1985) 293–302.

    Google Scholar 

  79. Moeschlin, S., (Ed), Klinik und Therapie der Vergiftungen. 6th edn. G. Thieme, Stuttgart 1980.

    Google Scholar 

  80. Müller-Fahlbusch, H., and Wöhning, T., Psychosomatische Untersuchung der mit Amalgamfüllungen in Verbindung gebrachten Beschwerden. Dt. zahnärztl. Z.38 (1983) 663–667.

    Google Scholar 

  81. Nordin, J., Yrkessjukdomar. Almqvist & Wiksell (1943) 184.

  82. Nylander, M., Friberg, L., and Lind, B., Mercury concentrations in the human brain and kidneys in relation to exposure from dental amalgam fillings. Swed. dent. J.11 (1987) 179–187.

    Google Scholar 

  83. Nylander, M., Mercury in pituitary glands of dentists. Lancet1 (1986) 442.

    Google Scholar 

  84. Nystrand, A., Amalgam. Läkartidn.83 (1986) 505–522.

    Google Scholar 

  85. Oettingen, W.F., von, (Ed), Poisoning. A Guide to Clinical Diagnosis and Treatment. Saunder Co., 1958.

  86. Patterson, J. E., Weissberg, B. G., and Dennison, P. J., Mercury in human breath from dental amalgams. Bull. envir. Contam. Toxic.34 (1985) 459–468.

    Google Scholar 

  87. Pelletier, L., Pasquier, R., Hirsch, F., Sapin, C., and Druet, P., In vivo self-reactivity of mononuclear cells to T cells and macrophages exposed to HgCl2. Eur. J. Immunol.15 (1985) 460–465.

    Google Scholar 

  88. Pleva, J., Mercury poisoning from dental amalgam. J. orthomol. Psychiat.12 (1983) 184–193.

    Google Scholar 

  89. Pleva, J., Corrosion and mercury release from dental amalgam. J. orthomol. Med.4 (1989) 141–158.

    Google Scholar 

  90. Poulsson, E., (Ed), Lehrbuch der Pharmakologie. 6th edn. 1922, 16th edn 1949.

  91. Rahola, T., Hattula, T., Korolainen, A., and Miettinen, J. K., Elimination of free and protein-bound ionic mercury (203Hg2+) in man. Ann. clin. Res.5 (1973) 214–219.

    Google Scholar 

  92. Rehde, O., (Ed), Invalidiserande huvudvärk, pp. 117–121. R-Dental AB, Falun, Sweden 1985. (ISBN 91-7810-137-9.)

  93. Robinson, C. J. G., Abraham, A. A., and Balazs, T., Induction of anti-nuclear antibodies by mercuric chloride in mice. Clin. exp. Immunol.58 (1984) 300–306.

    Google Scholar 

  94. Rost, A., Amalgamschäden. Zahnärztl. Prax.20 (1976) 475–480.

    Google Scholar 

  95. Rupp, N. W., and Pfaffenberger, G. O., Significance to health of mercury used in dentistry: a review. J. Am. dent. Ass.82 (1971) 1401–1407.

    Google Scholar 

  96. Sapin, C., Mandet, C., Druet, E., Günther, G., and Druet, P., Immune complex type disease induced by HgCl2: Genetic control of susceptibility. Transpl. Proc.13 (1981) 1404–1406.

    Google Scholar 

  97. Sakar, N. K., Marshall, G. W., Moser, J. B., and Greener, E. H., In vivo and in vitro corrosion products of dental amalgam. J. dent. Res.54 (1975) 1031–1038.

    Google Scholar 

  98. Schneider, V., Untersuchungen zur Quecksilberabgabe aus Silberamalgam-Füllungen mit Hilfe flammenloser Atomabsorption. Dt. zahnärztl. Z.32 (1977) 475–476.

    Google Scholar 

  99. Schneider, P. E., and Sarkar, N. K., Mercury release from Dispersalloy amalgam. 1982, IADR Abstr. No. 630.

  100. Schoonover, I. C., and Souder, W., Corrosion of dental alloys. J. Am. dent. Ass.28 (1941) 1278–1291.

    Google Scholar 

  101. Schulz, H., Wirkung und Anwendung der inorganischen Arzneistoffe. G. Thieme, Leipzig 1907.

    Google Scholar 

  102. Sies, H., (Ed.), Oxidative Stress. Academic Press, London 1985.

    Google Scholar 

  103. Smith, D. L. Jr., Mental effects of mercury poisoning. South. med. J.71 (1978) 904–905.

    Google Scholar 

  104. Smith, R. G., Vorwald, A. J., Patil, L. S., and Mooney, T. F., Effects of exposure to mercury in the manufacture of chlorine, Am. ind. Hyg. Ass. J.31 (1970) 687–700.

    Google Scholar 

  105. Snapp, K. R., Boyer, D. B., Peterson, L. C., and Svare, C. W., The contribution of dental amalgam to mercury in blood, J. dent. Res.68 (1989) 780–785.

    Google Scholar 

  106. Steffensen, K., Om kronisk kvicksölvforgiftning foraarsaget af tandplomber. Ugeskr. Laeg.96 (1934) 855–858.

    Google Scholar 

  107. Stock, A., Die Gefährlichkeit des Quecksilberdampfes. Z. angew. Chem.39 (1926) 461–466.

    Google Scholar 

  108. Stock, A., Die Gefährlichkeit des Quecksilberdampfes und der Amalgame. Med. Klin.22 (1926) 1250–1252.

    Google Scholar 

  109. Stock, A., Die Gefährlichkeit des Quecksilbers und der Amalgam-Zahnfüllungen. Z. angew. Chem.41 (1928) 663–672.

    Google Scholar 

  110. Stock, A., Die chronische Quecksilber- und Amalgamvergiftung, Arch. Gewerbepath.7 (1936) 388–413.

    Google Scholar 

  111. Stock, A., Die chronische Quecksilber- und Amalgamvergiftung. Zahnärztl. Rundschau10 (1939) 403–407.

    Google Scholar 

  112. Stock, A., and Cucuel, F., Der Quecksilbergehalt der menschlichen Ausscheidungen und des menschlichen Blutes. Z. angew. Chem.47 (1934) 641–647.

    Google Scholar 

  113. Stock, A., and Heller, R., Die Bestimmung kleiner Quecksilbermengen. Z. angew. Chem.39 (1926) 466–468.

    Google Scholar 

  114. Storlazzi, E. D., and Elkins, H. B., The significance of urinary mercury. I. Occupational mercury exposure. II. Mercury absorption from mercury-bearing dental fillings and antiseptics. J. ind. Hyg. Toxic.23 (1941) 459–465.

    Google Scholar 

  115. Struntz, H., (Ed.), Verrat an Deiner Gesundheit. Albert Amann Verlag, München 1956.

    Google Scholar 

  116. Stutte, H., and Groh, I., Zur Neuropathologie der Quecksilbervergiftung im Kindesalter. Fortschr. Neurol. Psychiat.29 (1961) 464–474.

    Google Scholar 

  117. Störtebecker, R., Direct transport of mercury from the oronasal cavity to the cranial cavity as a cause of dental amalgam poisoning. Swed. J. Biol. Med.3 (1989) 8–21.

    Google Scholar 

  118. Svare, C. W., Peterson, L. C., Reinhardt, J. W., Boyer, D. B., Frank, C. W., Gay, D. D., and Cox, R. D., The effect of dental amalgams on mercury levels in expired air. J. dent. Res.60 (1981) 1668–1671.

    Google Scholar 

  119. Taskinen, H., Kinnunen, E., and Riihimäki, V., A possible case of mercury-related toxicity resulting from the grinding of old amalgam restorations, Scand. J. envir. Hlth15 (1989) 302–304.

    Google Scholar 

  120. Till, T., and Maly, K., Zum Nachweis der Lyse von Hg aus Silberamalgam von Zahnfüllungen, Der Praktische Arzt32 (1978) 1042–1056.

    Google Scholar 

  121. Till, T., Untersuchungen über den Temperatureinfluss auf elektrochemische Vorgänge an metallischen Zahnreparaturmaterialien. Zahnärztl. Welt/Reform83 (1974) 980–982.

    Google Scholar 

  122. Tompsett, S. L., and Smith, D. C., Mercury in biological materials. J. clin. Path.12 (1959) 219–221.

    Google Scholar 

  123. Trachtenberg, I. M., (Ed.), Chronic Effects of Mercury on Organisms. Transl. from Russian. U.S. Dept. of Health, Education and Welfare DHEW Publ. 74–473, 1974.

  124. Uetrech, J., Mechanism of hypersensitivity reactions: proposed involvement of reactive metabolites generated by activated leukocytes. Trends pharmac. Sci.10 (1989) 463–467.

    Google Scholar 

  125. Vimy, M. J., and Lorscheider, F. L., Intra-oral mercury released from dental amalgam, J. dent. Res.64 (1985) 1069–1071.

    Google Scholar 

  126. Vimy, M. J., and Lorscheider, F. L., Serial measurements of intraoral air mercury: estimation of daily does from dental amalgam. J. dent. Res.64 (1985) 1072–1075.

    Google Scholar 

  127. Vimy, M. J., Takahashi, Y., and Lorscheider, F. L., Maternal-fetal distribution of mercury (203Hg) released from dental amalgam fillings. Am. J. Physiol.258 (1990) R939-R945.

    Google Scholar 

  128. Viola, P. L., L'influenza del cloro sull'intossicazione da vapori di mercurio. Med. Lavoro58 (1967) 60–65.

    Google Scholar 

  129. Viola, P. L., and Cassano, G. B., The effect of chlorine on mercury vapor intoxication. Autoradiographic study. Med. Lavoro59 (1968) 437–444.

    Google Scholar 

  130. Vrijhoef, M. M. A., Vermeersch, A. G., and Spanauf, A. J., Dental Amalgam. Quintessence Publ. Co. Inc. 1980.

  131. Wagner, E., Beitrag zur Klärung des Korrosionsverhaltens der Silber-Zinn Amalgame. Dt. zahnärztl. Z.17 (1962) 99–106.

    Google Scholar 

  132. Walls, A. W. G., Wallwork, M. A., Holland, I. S., and Murray, J. J., The longevity of occlusal amalgam restorations in first permanent molars of child patients, Br. dent. J.158 (1985) 133–136.

    Google Scholar 

  133. Warkany, J., Acrodynia—Postmortem of a disease. Am. J. Dis. Child.112 (1966) 147–156.

    Google Scholar 

  134. Warkany, J., and Hubbard, D. M., Acrodynia and mercury. J. Pediatr.42 (1953) 365–386.

    Google Scholar 

  135. Webb, J. L., (Ed.), Enzyme and metabolic inhibitors, vol. 2, pp. 841. Academic Press, London 1966.

    Google Scholar 

  136. Wesselhaeft, W. P., A few suggestions about mercurial fillings for teeth. Proc. int. Hannemann Ass.16 (1896) 200–209.

    Google Scholar 

  137. Zamm, A. V., Candida albicans therapy. Is there ever an end to it? Dental mercury removal: an effective adjunct. J. orthomol. Med.1 (1986) 261–266.

    Google Scholar 

  138. Zangger, H., Erfahrungen über Quecksilbervergiftungen. Arch. Gewerbepath.1 (1930) 539–560.

    Google Scholar 

  139. Ziff, M. F., and Ziff, S., Tracking the elusive mercury TLV. Bio-Probe Newsletter 3, dec. 1986, 1–24 (Editorial office 4401 Real Ct., Orlando, Fl. 32 808, USA.)

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hanson, M., Pleva, J. The dental amalgam issue. A review. Experientia 47, 9–22 (1991). https://doi.org/10.1007/BF02041243

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02041243

Key words

Navigation