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Identification of crystals of the rimino-phenazine compound B663 (lamprene: Clofazimine) in mouse spleen macrophages by thin layer chromatography and mass spectrum analysis

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Zusammenfassung

Die Rimino-Phenazin-Verbindung (Präparat B663 — Lampren® Clofazimine) mit starker Wirkung gegenMycobacterium leprae wurde 41/2 Monate an Mäuse verfüttert. Lichtmikroskopisch, dünnschichtchromatographisch und massenspektrometrisch wurde festgestellt, dass die B663-Kristalle im Cytoplasma der Makrophagen mit den in der Grundsubstanz vorhandenen identisch sind.

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Authors and Affiliations

  1. The Dyson Perrins Laboratory, Oxford, (England)

    R. T. Aplin & A. C. McDougall

  2. Department of Human Anatomy, Oxford University, South Parks Road, OX1 3QX, Oxford, (England)

    R. T. Aplin & A. C. McDougall

Authors
  1. R. T. Aplin
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  2. A. C. McDougall
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Additional information

Acknowledgments. We are indebted to Dr.R. J. W. Rees of the National Institute for Medical Research, Mill Hill, London for kindly supplying mice and the original B663 used in this experiment, and to Dr.M. L. Conalty for specimens of various riminophenazines from his laboratory in Trinity College, Dublin. This work is supported by grants toA. C. McDougall from the Medical Research Council and the British Leprosy Relief Association (LEPRA).

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Aplin, R.T., McDougall, A.C. Identification of crystals of the rimino-phenazine compound B663 (lamprene: Clofazimine) in mouse spleen macrophages by thin layer chromatography and mass spectrum analysis. Experientia 31, 468–469 (1975). https://doi.org/10.1007/BF02026384

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