Agents and Actions

, Volume 6, Issue 6, pp 758–769

Molybdenum toxicity: Interactions between copper, molybdenum and sulphate

  • M. A. Pitt
Models in Toxicology Review

DOI: 10.1007/BF02026100

Cite this article as:
Pitt, M.A. Agents and Actions (1976) 6: 758. doi:10.1007/BF02026100


Molybdenum toxicity and the interactions between copper, molybdenum and sulphate are reviewed. The main signs of molybdenum poisoning are poor growth and anaemia (rat, chick, rabbit, cattle and sheep), anorexia (rat), diarrhoea and achromotrichia (cattle and sheep), joint and bone deformities (rat, rabbit, cattle), central nervous system degeneration and loss of crimp in wool (sheep). The following topics are discussed:
  1. (1)

    The effect of sulphate and sulphur compounds on molybdenum toxicity.

  2. (2)

    The effect of molybdenum on tissue copper levels.

  3. (3)

    The effect of molybdenum on the distribution of copper in plasma.

  4. (4)

    The effect of molybden8m on uptake and excretion of copper.

  5. (5)

    The possible existence of copper(II) molybdate in vivo.

  6. (6)

    The influence of molybdenum on sulphide production by ruminal micro-organisms.

  7. (7)

    Competition between molybdenum and sulphate in intestinal transport.

  8. (8)

    Interaction of sulphur with copper in vivo.

  9. (9)

    The possible involvement of molybdenum in gout and multiple sclerosis in humans.


Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • M. A. Pitt
    • 1
  1. 1.Wallaceville Animal Research Centre, Research DivisionMinistry of Agriculture and FisheriesUpper HuttNew Zealand