Journal of Mammary Gland Biology and Neoplasia

, Volume 1, Issue 3, pp 259-269

First online:

Milk-borne prolactin and neonatal development

  • Lorie A. EllisAffiliated withDepartment of Nutrition, The Pennsylvania State University
  • , Andrea M. MastroAffiliated withDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University
  • , Mary Frances PiccianoAffiliated withDepartment of Nutrition, The Pennsylvania State University Email author 

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Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, especially early milk. The premise that prolactin (PRL) in milk is an important and possibly essential developmental factor for the newborn is explored. Both PRL and structurally modified isoforms are abundant in early milk and gradually diminish with the progression of lactation. Milk PRL is absorbed and biologically active in the neonate. Assays of PRL variants, experimental paradigms to test them as developmental regulators and the body of evidence supporting the hypothesis that milk PRL regulates differentiation and maturation of neonatal neuroendocrine, reproductive, and immune systems is presented.

Key words

Milk prolactin neonatal development immunity neuroendocrine reproduction pituitary