Journal of Mammary Gland Biology and Neoplasia

, Volume 1, Issue 3, pp 259–269

Milk-borne prolactin and neonatal development

Authors

  • Lorie A. Ellis
    • Department of NutritionThe Pennsylvania State University
  • Andrea M. Mastro
    • Department of Biochemistry and Molecular BiologyThe Pennsylvania State University
    • Department of NutritionThe Pennsylvania State University
Article

DOI: 10.1007/BF02018079

Cite this article as:
Ellis, L.A., Mastro, A.M. & Picciano, M.F. J Mammary Gland Biol Neoplasia (1996) 1: 259. doi:10.1007/BF02018079

Abstract

Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, especially early milk. The premise that prolactin (PRL) in milk is an important and possibly essential developmental factor for the newborn is explored. Both PRL and structurally modified isoforms are abundant in early milk and gradually diminish with the progression of lactation. Milk PRL is absorbed and biologically active in the neonate. Assays of PRL variants, experimental paradigms to test them as developmental regulators and the body of evidence supporting the hypothesis that milk PRL regulates differentiation and maturation of neonatal neuroendocrine, reproductive, and immune systems is presented.

Key words

Milk prolactinneonatal developmentimmunityneuroendocrinereproductionpituitary

Abbreviations

CD

Cluster of differentiation

G-PRL

glycosylated prolactin

IEL

intraepithelial lymphocytes

PCR

polymerase chain reaction

PRL

prolactin

PRL-R

prolactin receptor

RIA

radio-immunoassay

TC

cytotoxic T lymphocytes

Th

T-helper lymphocytes

TIDA

tuberoinfundibular dopaminergic

Copyright information

© Plenum Publishing Corporation 1996