Abstract
The eponym “Binswanger's disease” is frequently used to indicate a form of vascular dementia characterized by white matter rarefaction and lacunar infarcts; however, it is difficult to find any consistency between this picture and the single case reported by Binswanger in 1894, which was vaguely defined both clinically and pathologically, and was probably a case of neurosyphilis.
The first Italian report of a case of “Binswanger's disease” was published in 1958 by Donegani and Grattarola, who described a patient with a history of manic episodes followed by progressive mental deterioration. Pathological examination revealed changes mainly located in the hemispheric white matter, and the authors defined the patient as being affected by Binswanger's encephalopathy. Re-evaluation of this report indicates that the term “Binswanger's disease” has been applied to cases with non-specific clinical and pathological characteristics in the past.
In this paper, we briefly compare Binswanger's original and the 1958 Italian case report, and discuss the current use of the term “Binswanger's disease”.
Sommario
L'eponimo “malattia di Binswanger” è frequentemente usato per indicare una forma di demenza vascolare caratterizzata da rarefazione della sostanza bianca emisferica ed infarti lacunari. Tuttavia, è difficile individuare una stretta analogia fra tale quadro e quello riportato da Binswanger nel 1894 in un singolo paziente vagamente definito sia clinicamente che patologicamente, e interpretabile come un caso di neurosifilide.
Nel 1958 Donegani e Grattarola descrissero il caso di un paziente affetto da episodi maniacali seguiti da progressivo decadimento mentale. L'esame patologico rivelò alterazioni localizzate principalmente nella sostanza bianca. Gli autori definirono il caso come affetto da encefalopatia di Binswanger. Questa può essere considerata la prima pubblicazione italiana sulla “malattia di Binswanger”. La revisione dell'articolo indica che già nel passato il termine “malattia di Binswanger” è stato applicato a casi con caratteristiche clinico-patologiche non specifiche.
Vengono rivisiti e comparati il caso originale di Binswanger e quello italiano del 1958. Inoltre si avanzano delle considerazioni sull'uso corrente del termine “malattia di Binswanger”.
Similar content being viewed by others
References
Alzheimer A.:Die Seelenstörungen auf arteriosklerotischer Grundlage. Allg. Z. Psychiat. 59: 695–701, 1902.
Bennett D.A., Wilson R.S., Gilley D.W., Fox J.H.:Clinical diagnosis of Binswanger's disease. J. Neurol. Neurosurg. Psychiatry 53: 961–965, 1990.
Binswanger O.:Die Abgrenzung der allgemeinen progressiven Paralyse. Berl. Klin. Wochenschr 31: 1102–1105, 1137–1139, 1180–1186, 1894.
Blass J.P., Hoyer S., Nitsch R.:A translation of Otto Binswanger's article, “The delineation of the generalized progressive paralyses”. Arch. Neurol. 48: 961–972, 1991.
Brun A.:Pathology and pathophysiology of cerebrovascular dementia: pure subgroups of obstructive and hypoperfusive etiology. Dementia 5: 145–147, 1994.
Brun A., Englund E.:A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann. Neurol. 19: 253–262, 1986.
Caplan L.R.:Binswanger's disease — revisited. Neurology 45: 626–633, 1995.
Corbett A., Bennett H., Kos S.:Cognitive dysfunction following subcortical infarction. Arch. Neurol. 51: 999–1007, 1994.
Davison C.:Progressive subcortical encephalopathy (Binswanger's disease). J. Neuropathol. Exp. Neurol. 1: 42–48, 1942.
Donegani G., Grattarola F.R.:Considerazioni anatomo-cliniche sulla encefalopatia sottocorticale cronica di Binswanger. Schweiz Arch. Neurol. Psychiatr. 81: 132–143, 1958.
Farnell F.J., Globus J.H.:Chronic progressive vascular subcortical encephalopathy. Chronic progressive subcortical encephalitis of Binswanger. Arch. Neurol. Psychiatry 27: 593–604, 1932.
Feigin I., Popoff N.:Neuropathological changes late in cerebral edema: the relationship to trauma, hypertensive disease and Binswanger's encephalopathy. J. Neuropathol. Exp. Neurol. 22: 500–511, 1963.
George A.E.:Chronic communicating hydrocephalus and periventricular white matter disease: a debate with regard to cause and effect. AJNR Am. J. Neuroradiol. 12: 42–44, 1991.
Hachinski V.:Binswanger's disease: neither Binswanger's nor a disease. J. Neurol. Sci. 103: 1, 1991.
Hachinski V.C., Potter P., Merskey H.:Leuko-araiosis. Arch. Neurol. 44: 21–23, 1987.
Hunt A.L., Orrison W.W., Yeo R.A. et al.:Clinical significance of MRI white matter lesions in the elderly. Neurology 39: 1470–1474, 1989.
Kinkel W.R., Jacobs L., Polachini I., Bates V., Heffner R.R.:Binswanger's disease. Arch. Neurol. 43: 641–642, 1986.
Olszewski J.:Subcortical arteriosclerotic encephalopathy. World Neurol. 3: 359–375, 1962.
Pantoni L., Garcia J.H.:The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke 26: 1293–1301, 1995.
Pantoni L., Garcia J.H.:Binswanger's disease: what's in a name? Cerebrovasc. Dis., in press.
Román G.C.:Senile dementia of the Binswanger type: a vascular form of dementia in the elderly. JAMA 258: 1782–1788, 1987.
Román G.C.:Why not Binswanger's disease? Arch. Neurol. 45: 141–142, 1988.
Schneider R., Wieczorek V.:Otto Binswanger (1852–1929). J. Neurol. Sci. 103: 61–64, 1991.
Schorer C.E., Rodin E.A.:Binswanger's disease: a complete translation. J. Geriatr. Psychiatry Neurol. 3: 61–66, 1990.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pantoni, L., Moretti, M. & Inzitari, D. The first italian report on “Binswanger's disease”. Ital J Neuro Sci 17, 367–370 (1996). https://doi.org/10.1007/BF01999900
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01999900