Abstract
Toxigenic bacteria such asBordetella pertussis andStaphylococcus aureus have been implicated in some cases of sudden infant death syndrome (SIDS). We have previously demonstrated that the Lewisa antigen is an epithelial cell receptor forS. aureus, and this study demonstrated that Lewisa on human monocytes is also a receptor for staphylococcal enterotoxin B (SEB). Values obtained in assays for production of TNF-alpha and nitric oxide were greater for monocytes treated with SEB compared with those treated with lipopolysaccharide (LPS). Exposure to LPS increased the expression of Lewisa on monocytes. These results are discussed with reference to the reported enhancement of endotoxic shock by pyrogenic toxins.
Similar content being viewed by others
References
A. Nicholl and A. Gardner,Whooping cough and unrecognized post-perinatal mortality. Arch. Dis. Child.63, 41–47 (1988).
C. C. Blackwell, A. T. Saadi, M. W. Raza, D. M. Weir and A. Busuttil,The potential role of bacterial toxins in sudden infant death syndrome. Int. J. Legal Med.10, 333–338 (1993).
G. A. Bohach, D. J. Fast, R. D. Nelson and P. M. Schlievert,Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses. Crit. Rev. Microbiol.17, 251–272 (1990).
J. vant' Wout, W. N. Burnette, V. L. Mar, E. Rozdzinski, S. D. Wright and E. Tuomanen,Role of carbohydrate recognition domains of pertussis toxin in adherence of Bordetella pertussis to human macrophages. Infect. Immunol.60, 3303–3308 (1992).
A. T. Saadi, C. C. Blackwell, M. W. Raza, V. S. James, J. Stewart, R. A. Elton and D. M. Weir,Factors enhancing adherence of toxigenic staphylococci to epithelial cells and their possible role in sudden infant death syndrome. Epidemiol. Infect.110, 507–517 (1993).
I. C. Green, D. A. Wagner, J. Glogowski, P. I. Skipper, J. S. Wishnok and S. R. Tannenbaum,Analysis of nitrate, nitrite, and [5 N] nitrate in biological fluids. Analyt. Biochem.126, 131–138 (1982).
S. J. Twite, S. D. Essery, A. T. Saadi, M. W. Raza, C. C. Blackwell and D. M. Weir,Monocytes: The “Trojan horses” of meningocccal disease. J. Med. Microbiol.39 (Suppl), 343 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Essery, S.D., Saadi, A.T., Twite, S.J. et al. Lewis antigen expression on human monocytes and binding of pyrogenic toxins. Agents and Actions 41, 108–110 (1994). https://doi.org/10.1007/BF01986408
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01986408