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N-methyl-N-formylhydrazine: A toxic and mutagenic inhibitor of the intestinal diamine oxidase

  • Distribution and Metabolism of Histamine
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Abstract

N-methyl-N-formylhydrazine is the first active intermediate of the poison gyromitrin of the mushroom: false morel. This compound is a non-competitive inhibitor of human intestinal diamine oxidase (ID50=1.6×10−5 mol/l). This concentration corresponds to less than 5g of wet weight of mushroom/l. The diamine oxidases from 5 other sources are inhibited in a similar manner. Semicarbazide and aminoguanidine are 10-respectively 1000-fold more potent inhibitors of the human intestinal diamine oxidase. An involvement of the diamine oxidase inhibitory property ofN-methyl-N-formylhydrazine in toxic and mutagenic effects of the substance is considered.

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Authors and Affiliations

  1. Department of Biogenic Amines, Institute of Pharmacology, Lódź, Poland

    T. Biegński

  2. Bundesgesundheitsamt Berlin, FRG

    R. Braun

  3. Biochemical and Experimental Division, II. Department of Surgery, University of Cologne, Ostmerheimerstraße 200, 5000, Köln 91, FRG

    J. Kusche

Authors
  1. T. Biegński
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  2. R. Braun
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  3. J. Kusche
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Supported by Alexander von Humboldt-Stiftung.

Supported by a grant from Deutsche Forschungsgemeinschaft (Ku 464/1)

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Biegński, T., Braun, R. & Kusche, J. N-methyl-N-formylhydrazine: A toxic and mutagenic inhibitor of the intestinal diamine oxidase. Agents and Actions 14, 351–355 (1984). https://doi.org/10.1007/BF01973825

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