Skip to main content
SpringerLink
Log in

Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin

  • Published:
Experientia Aims and scope Submit manuscript

Summary

Endotoxin treated with chromium chloride is less toxic to mice than the parent molecule, but can disrupt intestinal permeability barriers and has an enhanced ability to activate Hageman factor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S.J. Prigal, A. Herp and J. Gerstein, J. Reticuloend. Soc.14, 250 (1973).

    CAS  Google Scholar 

  2. S.L. Snyder, R.I. Walker, T.J. McVittie and J.M. Sheil, Can. J. Microbiol., in press (1978).

  3. O.D. Ratnoff, in: Immunobiology, p. 135. Ed. R.A. Good and D.W. Fisher, Sinauer Associates Inc., Stanford 1971.

    Google Scholar 

  4. J.W. Mason, U. Kleeberg, P. Dolan and R.W. Colman, Ann. intern. Med.73, 545 (1970).

    Article  CAS  PubMed  Google Scholar 

  5. H.R. Kimball, K.L. Melmon and S.M. Wolff Proc. Soc. exp. Biol. Med.139, 1078 (1972).

    Article  CAS  PubMed  Google Scholar 

  6. R.I. Walker and M. Porvaznik, Infect. Immun., in press (1978).

  7. D.T. Caridis, M. Ishiyama, P.W.H. Woodruff and J. Fine, J. Reticuloend. Soc.14, 513 (1973).

    CAS  Google Scholar 

  8. C.B. Galley, R.I. Walker, G.D. Ledney and M.R. Gambrill, Exptl Hemat.3, 13 (1975).

    Google Scholar 

  9. R.M. Hardisty and J.C. Macpherson, Thromb. Diath. haemorrh.7, 215 (1962).

    CAS  PubMed  Google Scholar 

  10. P. Klir, J. Pospisil, E. Skala, Z. Dienstbier and O. Tacheci, Strahlentherapie146, 713 (1973).

    CAS  PubMed  Google Scholar 

  11. J. Aznar, J. Mayans and J.A. Aznar, Haemostasis3, 20 (1974).

    CAS  PubMed  Google Scholar 

  12. R.I. Walker, S.L. Snyder, P.Z. Sobocinski, K.F. McCarthy and J.E. Egan, Can. J. Microbiol., in press (1978).

  13. E. Suter, in: Bacterial Endotoxin. Ed. M. Landy and W. Braun. Institute of Microbiology, New Brunswick, NJ, 1964.

    Google Scholar 

  14. R.I. Walker, G.D. Ledney and C.B. Galley, Radiat. Res.62, 242 (1975).

    Article  CAS  PubMed  Google Scholar 

  15. D.C. Morrison and C. Cochrane, J. exp. Med.140, 797 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. S.D. Revak and C.G. Cochrane, Thromb. Haemostasis3, 520 (1976).

    Google Scholar 

  17. D.M. Zubairov and L.G. Popova, Thromb. Res.8, 587 (1976).

    Article  CAS  PubMed  Google Scholar 

  18. R.G. Lerner, S.I. Rapaport and J.M. Spitzer, Thromb. Diath. haemorrh.20, 430 (1968).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Experimental Hematology Department, Armed Forces Radiobiology Research Institute, 20014, Bethesda, Maryland, USA

    R. I. Walker, M. Porvaznik, June E. Egan & A. M. Miller

  2. Veterinary Medicine Department, Armed Forces Radiobiology Research Institute, 20014, Bethesda, Maryland, USA

    R. I. Walker, M. Porvaznik, June E. Egan & A. M. Miller

Authors
  1. R. I. Walker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Porvaznik
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. June E. Egan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. M. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

We wish to thank Drs M.W. Brightman and T.S. Reese from the Department of Neurocytology, National Institutes of Health for the use of their Balzers freeze-fracture instrument.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walker, R.I., Porvaznik, M., Egan, J.E. et al. Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin. Experientia 35, 759–762 (1979). https://doi.org/10.1007/BF01968230

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01968230

Keywords

Search

Navigation