Article

Experientia

, Volume 35, Issue 6, pp 759-762

Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin

  • R. I. WalkerAffiliated withExperimental Hematology Department, Armed Forces Radiobiology Research InstituteVeterinary Medicine Department, Armed Forces Radiobiology Research Institute
  • , M. PorvaznikAffiliated withExperimental Hematology Department, Armed Forces Radiobiology Research InstituteVeterinary Medicine Department, Armed Forces Radiobiology Research Institute
  • , June E. EganAffiliated withExperimental Hematology Department, Armed Forces Radiobiology Research InstituteVeterinary Medicine Department, Armed Forces Radiobiology Research Institute
  • , A. M. MillerAffiliated withExperimental Hematology Department, Armed Forces Radiobiology Research InstituteVeterinary Medicine Department, Armed Forces Radiobiology Research Institute

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Summary

Endotoxin treated with chromium chloride is less toxic to mice than the parent molecule, but can disrupt intestinal permeability barriers and has an enhanced ability to activate Hageman factor.