, Volume 35, Issue 6, pp 759-762

Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin

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Summary

Endotoxin treated with chromium chloride is less toxic to mice than the parent molecule, but can disrupt intestinal permeability barriers and has an enhanced ability to activate Hageman factor.

We wish to thank Drs M.W. Brightman and T.S. Reese from the Department of Neurocytology, National Institutes of Health for the use of their Balzers freeze-fracture instrument.