, Volume 39, Issue 5, pp 514-518

Disruption of the goblet cell intercellular junction following histamine infusion of the rabbit ileum

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Histamine infused into the mesenteric artery of the rabbit ileum ruptured tight junctional complexes linking goblet cells with neighboring absorptive epithelial or other goblet cells. Loss of tight junctional integrity induced by histamine could contribute to extra-intestinal endotoxemia reported after a variety of injuries.

Supported by Armed Forces Radiobiology Research Institute, Defense Nuclear Agency, under Research Work Unit MJ 60204. The views presented in this paper are those of the authors. No endorsement by the Defense Nuclear Agency has been given or should be inferred.
Research was conducted according to the principles enunciated in the ‘Guide for the Care and Use of Laboratory Animals’, prepared by the Institute of Laboratory Animal Resources, National Research Council.
We thank Luther G. Milton, Jr, for his assistance as surgical technician, Joseph L. Parker for preparing the tissue for microscopy, and Donna Boyle for editorial assistance. We thank the Departments of Anatomy at the Uniformed Services University of Health Sciences and the University of Chicago Medical School for the use of their Balzers freeze-fracture apparatus.