Article

Experientia

, Volume 39, Issue 5, pp 514-518

Disruption of the goblet cell intercellular junction following histamine infusion of the rabbit ileum

  • M. PorvaznikAffiliated withExperimental Hematology Department, Armed Forces Radiobilogy Research Institute
  • , W. BakerAffiliated withExperimental Hematology Department, Armed Forces Radiobilogy Research Institute
  • , R. I. WalkerAffiliated withExperimental Hematology Department, Armed Forces Radiobilogy Research Institute

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Summary

Histamine infused into the mesenteric artery of the rabbit ileum ruptured tight junctional complexes linking goblet cells with neighboring absorptive epithelial or other goblet cells. Loss of tight junctional integrity induced by histamine could contribute to extra-intestinal endotoxemia reported after a variety of injuries.