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Correlation of immunogenicity with suppression of lymphocyte adenosine 3′,5′-monophosphate-dependent protein kinase

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Summary

Cyclic-AMP-dependent protein kinase activity was depressed in whole spleen as well as in isolated splenic lymphocytes from 3-methylcholanthrene (MCA), R3230 AdCa mammary adenocarcinoma, N-hydroxy-2-acetylaminofluorene, and 4-dimethylaminoazobenzene (DMAAB) tumor-bearing Fischer rats as compared to control animals. The magnitude of depression increased with the immunogenicity of the tumor. The depressed enzyme activity was the result of a reduced Vmax for adenosine 3′,5′-monophosphate (cAMP)-stimulated histone phosphorylation.

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  1. A. A. Hakim

    Present address: , 180 Longwood Drive, 60901, Kankakee, Illinois, USA

Authors and Affiliations

  1. Department of Physiology and Biophysics and Oral Diagnosis, The Graduate College and College of Dentistry of the University of Illinois at the Medical Center, 60680, Chicago, Illinois, USA

    A. A. Hakim

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  1. A. A. Hakim
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Hakim, A.A. Correlation of immunogenicity with suppression of lymphocyte adenosine 3′,5′-monophosphate-dependent protein kinase. Experientia 35, 1378–1380 (1979). https://doi.org/10.1007/BF01964019

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