European Journal of Pediatrics

, Volume 149, Issue 10, pp 734–737

Cotinine concentrations in amniotic fluid and urine of smoking, passive smoking and non-smoking pregnant women at term and in the urine of their neonates on 1st day of life

  • J. S. Jordanov

DOI: 10.1007/BF01959534

Cite this article as:
Jordanov, J.S. Eur J Pediatr (1990) 149: 734. doi:10.1007/BF01959534


Cotinine was measured in the amniotic fluid and urine of 31 pregnant women and in the urine of their offspring. Amniotic fluid cotinine was 8 times higher in active and 2.5 times higher in passive smokers than in non-smokers. In general, amniotic fluid cotinine was considerably higher than urinary cotinine both in active and in passive smokers. Estimation of cotinine both in amniotic fluid immediately before delivery and in urine of the newborn on the 1st day of life aids in assessing the degree of prenatal exposure to tobacco smoke.

Key words

Pregnancy Fetus Neonate Smoking and passive smoking Cotinine concentrations in amniotic fluid and urine 



direct barbituric acid method


environmental tobacco smoke

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • J. S. Jordanov
    • 1
  1. 1.Department of Biochemistry, Research Institute of PaediatricsMedical AcademySofiaBulgaria

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