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Cotinine concentrations in amniotic fluid and urine of smoking, passive smoking and non-smoking pregnant women at term and in the urine of their neonates on 1st day of life

  • Neonatology
  • Published:
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Abstract

Cotinine was measured in the amniotic fluid and urine of 31 pregnant women and in the urine of their offspring. Amniotic fluid cotinine was 8 times higher in active and 2.5 times higher in passive smokers than in non-smokers. In general, amniotic fluid cotinine was considerably higher than urinary cotinine both in active and in passive smokers. Estimation of cotinine both in amniotic fluid immediately before delivery and in urine of the newborn on the 1st day of life aids in assessing the degree of prenatal exposure to tobacco smoke.

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Abbreviations

DBA:

direct barbituric acid method

ETS:

environmental tobacco smoke

References

  1. Andresen RD, Ng KJ, Iams JD, Bianchine JR (1982) Cotinine in amniotic fluids from passive smokers. Lancet I:791–792

    Article  Google Scholar 

  2. Barlow RD, Stone RB, Wald NJ, Puhakainen EVJ (1987) The direct barbituric acid assay for nicotine metabolites in urine: a simple colorimetric test for the routine assessment of smoking status and cigarette smoke intake. Clin Chim Acta 165:45–52

    Article  PubMed  Google Scholar 

  3. Bergman AB, Wiesner LA (1976) Relationship of passivecigarette smoking to sudden infant death syndrome. Pediatrics 58:665–668

    PubMed  Google Scholar 

  4. Cnattingins S, Haglund B, Meiric O (1988) Cigarette smoking as risk factor for late fetal and early neonatal death. Br Med J 297:258–261

    Google Scholar 

  5. Etzel RA, Greenberg RA, Haley NJ, Loda FA (1985) Urine cotinine excretion in neonates exposed to tobacco smoke products in utero. J Pediatr 107:146–148

    PubMed  Google Scholar 

  6. Fergusson DM, Harwood IJ, Shannon FT (1979) Smoking during pregnancy. NZ Med J 89:41–43

    Google Scholar 

  7. Greenberg RA, Etzel RA, Haley NJ (1984) Letter to editor. N Engl J MEd 311:672

    PubMed  Google Scholar 

  8. Greenberg RA, Haley NJ, Etzel RA, Loda FA (1984) Measuring the exposure of infants to tobacco smoke. N Engl J Med 310:1075–1078

    PubMed  Google Scholar 

  9. Greenberg RA, Bauman KE, Glover LH, Strecher UV, Kleinbaum DG, Haley NJ, Stedman HC, Fowler MG, Loda FA (1989) Ecology of passive smoking by young infants. J Pediatr 114:774–780

    PubMed  Google Scholar 

  10. Gortmaker, SL, Walker DK, Jacobs FH (1982) Parental smoking and the risk of childhood asthma. Am J Public Health 72:574–579

    PubMed  Google Scholar 

  11. Haddow JE, Knight GJ, Palomaki GE, Haddow PK (1988) Estimating fetal morbidity and mortality resulting from cigarette smoke exposure by measuring cotinine levels in maternal serum. In: Liss AR (ed) Transplacental effects on fetal health. Elsevier, Amsterdam, pp 289–300

    Google Scholar 

  12. Hibberd AR, O'Connor V, Gorrod JW (1978) Detection of nicotine, nicotine-1′-N-oxide and cotinine in maternal and foetal body fluids. In: Gorrod JW (ed) Biological oxidation of nitrogen. Elsevier, Amsterdam, pp 353–361

    Google Scholar 

  13. Howe G, Westhoff C, Vessey M, Yeates D (1985) Effects of age, cigarette smoking, and other factors on fertility: findings in a large prospective study. Br Med J 290:1697–1700

    Google Scholar 

  14. Jordanov JSt, Miteva P, Romanova S (1988) Cotinine concentrations in urine during early childhood with smoking parents at home. In: Perry R, Kirk PW (eds) Indoor and ambient air quality. Selper, London, pp 224–231

    Google Scholar 

  15. Kline J, Stein ZA, Susser M, Warburton D (1977) Smoking: a risk factor for spontaneous abortion. N Engl J Med 297:793–796

    PubMed  Google Scholar 

  16. Kristjansson EA, Fried PA, Watkinson B (1989) Maternal smoking during pregnancy affect children's vigilance performance. Drug Alcohol Depend 24:11–21

    Article  PubMed  Google Scholar 

  17. Lebowitz MA, Holgerg, CJ (1988) Effects of parental smoking and other risk factors on the development of pulmonary function in children and adolescents. Am J Epidemiol 128:589–597

    PubMed  Google Scholar 

  18. Luck W, Nau H (1984) Exposure of the fetus, neonate and nursed infant to nicotine and cotinine from maternal smoking. N Engl J Med 311:672

    PubMed  Google Scholar 

  19. Luck W, Nau H (1985) Nicotine and cotinine concentrations in serum and urine of infants exposed via passive smoking or milk from smoking mothers. J Pediatr 107:816–820

    PubMed  Google Scholar 

  20. Manning FA, Feyerabend C (1976) Cigarette smoking and fetal breathing movements. Br J Obstet Gynaecol 83:262–270

    PubMed  Google Scholar 

  21. Matsukura S, Taminato T, Kitano N, Seino Y, Hamada H, Uchihashi M, Nakajima H, Hirata Y (1984) Effects of environmental tobacco smoke on urinary cotinine excretion in nonsmokers. N Engl J Med 311:828–832

    PubMed  Google Scholar 

  22. Meyer MB, Jonas BC, Tonascia JA (1976) Perinatal events associated with maternal smoking during pregnancy. Am J Epidemiol 103:464–476

    PubMed  Google Scholar 

  23. Mochizuki M, Maruo T, Masuko K, Ohtsu T (1984) Effects of smoking on fetoplacental-maternal system during pregnancy. Am J Obstet Gynaecol 149:413–420

    Google Scholar 

  24. Naeye RL, Peters EC (1984) Mental development of children whose mothers smoked during, pregnancy. Obstet Gynecol 64:601–607

    PubMed  Google Scholar 

  25. Nylund L, Lunell NO, Fredholm BB, Lagercrantz H (1979) Acute metabolic and circulatory effects of cigarette smoking in late pregnancy. Gynecol Obstet Invest 10:39–45

    PubMed  Google Scholar 

  26. Pershagen G (1989) Childhood cancer and malignancies other than lung cancer related to passive smoking. Mutat Res 222:129–135

    PubMed  Google Scholar 

  27. Persson PH, Grenenrt L, Gennser G (1984) A study of smoking and pregnancy with special reference to fetal growth. Acta Obstet Gynecol Scand 78 [Suppl]:33–39

    Google Scholar 

  28. Rivrud GN, Berg K, Anderson D, Plowers S (1986) Mutagenic effect of amniotic fluid from smoking women at term. Mutat Res 171:71–77

    PubMed  Google Scholar 

  29. Rylander E, Pershagen G, Curvall M, Kazemi-Vala E (1989) Exposure to environment tobacco smoke and urinary excretion of cotinine and nicotine in children. Acta Paediatr Scand 78:449–450

    PubMed  Google Scholar 

  30. Saxton DW (1978) The behaviour of infants whose mothers smoke in pregnancy. In: Early human development. Elsevier/North-Holland Biomedical Press, Amsterdam 2/4:363–369

    Google Scholar 

  31. Schwartz-Bickenbach D, Schulte-Hobein B, Abt S, Plum C, Nau H (1987) Smoking and passive smoking during pregnancy and early infancy: effects on birth weight, lactation period, and cotinine concentrations in mother's milk and infant's urine. Toxicol Lett 35:73–81

    Article  PubMed  Google Scholar 

  32. Shiono PH, Klebanoff MA, Rhoads GG (1986) Smoking and drinking during pregnancy: their effects on preterm of creatinine. Clin Chem 30:968–969

    Google Scholar 

  33. Smith NA, Austen J, Rolles CJ (1982) Tertiary smoking by the fetus. Lancet I:1252

    Article  Google Scholar 

  34. Taylor B, Wadsworth J (1987) Maternal smoking during pregnancy and lower respiratory tract illness in early life. Arch Dis Child 62:786–791

    PubMed  Google Scholar 

  35. Van Vunakis H, Lamgone JJ, Milusky A (1974) Nicotine and cotinine in the amniotic fluid of smokers in the second trimester of pregnancy. Am J Obstet Gynaecol 120:64–66

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Research Institute of Paediatrics, Medical Academy, 11, Dimiter Nestorov Str., 1606, Sofia, Bulgaria

    J. S. Jordanov

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  1. J. S. Jordanov
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Jordanov, J.S. Cotinine concentrations in amniotic fluid and urine of smoking, passive smoking and non-smoking pregnant women at term and in the urine of their neonates on 1st day of life. Eur J Pediatr 149, 734–737 (1990). https://doi.org/10.1007/BF01959534

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  • DOI: https://doi.org/10.1007/BF01959534

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