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Implication of C-5, C-6 unsaturation as a key structural factor in steroidal alkaloid-induced mammalian teratogenesis

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Abstract

Hamster teratogenicity induced upon oral administration of steroidal alkaloids (solanidanes, spirosolanes and jervanes) appears to relate very closely to the presence or absence of C-5, C-6 unsaturation in the alkaloid, which may be more important than molecular configuration at C-22 and placement of the nitrogen atom with regard to the plane of the steroid.

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Authors and Affiliations

  1. Western Regional Research Center, ARS, USDA, 94710, Albany, California, USA

    W. Gaffield

  2. Poisonous Plant Research Laboratory, ARS, USDA, 84321, Logan, Utah, USA

    R. F. Keeler

Authors
  1. W. Gaffield
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  2. R. F. Keeler
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Gaffield, W., Keeler, R.F. Implication of C-5, C-6 unsaturation as a key structural factor in steroidal alkaloid-induced mammalian teratogenesis. Experientia 49, 922–924 (1993). https://doi.org/10.1007/BF01952611

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  • DOI: https://doi.org/10.1007/BF01952611

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