Full Papers


, Volume 43, Issue 9, pp 998-1002

First online:

Dynamics of excretion of urinary chemosignals in the house mouse (Mus musclus) during the natural estrous cycle

  • F. AndreoliniAffiliated withDepartment of Chemistry, Indiana University
  • , B. JemioloAffiliated withDepartment of Chemistry, Indiana University
  • , M. NovotnyAffiliated withDepartment of Chemistry, Indiana University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


The volatile fraction of urinary metabolites was investigated chromatographically at five different stages of the natural estrous cycle. A very substantial endocrine dependency has been noted for 11 compounds: 4 ketones, 2 acetate esters, 3 dihydrofuran isomers, dehydro-exo-brevicomin, and 2,5-dimethylpyrazine. The compounds were structurally verified through combined gas chromatography/mass spectrometry.

Key words

Estrous cycle female mouse urine urinary volatiles capillary gas chromatography/mass spectrometry