Experientia

, Volume 40, Issue 11, pp 1240–1244

Effects of pre- and post-irradiation glucan treatment on pluripotent stem cells, granulocyte, macrophage and erythroid progenitor cells, and hemopoietic stromal cells

Authors

  • M. L. Patchen
    • Experimental Hematology DepartmentArmed Forces Radiobiology Research Institute
  • T. J. MacVittie
    • Experimental Hematology DepartmentArmed Forces Radiobiology Research Institute
  • L. M. Wathen
    • Experimental Hematology DepartmentArmed Forces Radiobiology Research Institute
Article

DOI: 10.1007/BF01946654

Cite this article as:
Patchen, M.L., MacVittie, T.J. & Wathen, L.M. Experientia (1984) 40: 1240. doi:10.1007/BF01946654

Summary

Glucan, a beta-1, 3 polyglucose, was administered to mice either 1 h before or 1 h after a 650 rad exposure to cobalt-60 radiation. Compared to radiation controls, glucan-treated mice consistantly exhibited a more rapid recovery of pluripotent stem cells and committed granulocyte, macrophage, and erythroid progenitor cells. This may partially explain the mechanism by which glucan also enhances survival in otherwise lethally irradiated mice.

Key words

Miceglucan treatmentCo60-irradiationstem cells, pluripotentgranulocytesmacrophageserythroid progenitor cellshemopoietic stomal cellshemopoiesis

Copyright information

© Birkhäuser Verlag 1984