The Journal of Membrane Biology

, Volume 21, Issue 1, pp 25–47

Determination of the resistance in series with the membranes of giant axons

  • L. Binstock
  • W. J. AdelmanJr.
  • J. P. Senft
  • H. Lecar
Article

DOI: 10.1007/BF01941060

Cite this article as:
Binstock, L., Adelman, W.J., Senft, J.P. et al. J. Membrain Biol. (1975) 21: 25. doi:10.1007/BF01941060
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Summary

Measurements of the resistance in series with the excitable membrane for giant axons of two different phylla (the squidLoligo pealii and the marine wormMyxicola infundibulum) were obtained. Efforts were made to take into account the errors introduced by the finite rise-time of the measuring apparatus. The series resistance value, obtained very quickly by the method described, may be used in setting the compensation potentiometer to offset this resistance in voltage-clamp measurements. Estimates of the resistance of the periaxonal tissue layer were made. Analyses were done on some of the problems involved in attempting to make an unambiguous determination of the series resistance.

Copyright information

© Springer-Verlag New York Inc. 1975

Authors and Affiliations

  • L. Binstock
    • 1
    • 2
  • W. J. AdelmanJr.
    • 1
    • 2
  • J. P. Senft
    • 1
    • 2
  • H. Lecar
    • 1
    • 2
  1. 1.The Laboratory of Biophysics, IR, National Institute of Neurological Diseases and Stroke, National Institutes of Health, U.S. Public Health ServiceDepartment of Health, Education and WelfareBethesda
  2. 2.Marine Biological LaboratoryWoods Hole
  3. 3.Juniata CollegeHuntington