Abstract
We compared the effects of 0.45% normal saline (NS), 5% Intralipid® (IL), and 16.7% glucose (Glu) infusions on total serum triglycerides and cholesterol, serum high-(HDL-c) and low-density lipoprotein cholesterol (LDL-c), and activity of serum lecithin: cholesterol acyltransferase (LCAT), and serum lipoprotein lipase (LPL) in rats implanted with a fibrosarcoma. In tumor-bearing rats given NS, a two-fold increase in total serum cholesterol, a four-fold increase in LDL-c, and a five-fold decrease in the HDL-c/LDL-c ratio were observed compared to tumor-free rats. In tumor-bearing rats administered IL, a two-fold increase in total serum triglyceride and cholesterol, a three-fold increase in HDL-c and HDL-c/LDL-c ratio, and a two-fold increase in LPL activity were observed compared to tumor-bearing rats administered NS. In tumor-bearing rats administered Glu, a two-fold decrease in total serum cholesterol, a two-fold decrease in HDL-c, and a three-fold decrease in LDL-c were observed compared to tumor-bearing rats administered NS. Tumor weights and LCAT activity did not differ significantly between treatment groups. Previous results have demonstrated that lipophilic compounds that interact with plasma lipoproteins have altered pharmacological effects when administered with IL. Therefore, this study suggests that IL infusions alter the HDL-c/LDL-c ratio and could affect the pharmacological behavior of anticancer compounds that predominantly distribute into the LDL fraction upon entrance into the bloodstream.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Hultin, M., Bengtsson-Olivecronia, G., and Olivecronia, T., Biochim. biophys. Acta1125 (1992) 97.
Griffin, E., Breckenridge, W. C., Kuksis, A., Bryan, M. H., and Angel, A., J. clin. Invest.64 (1979) 1703.
Breckenridge, W. C., Kakis, G., and Kuksis, A., Can. J. Biochem.57 (1979) 72.
Untracht, S. H., Biochim. biophys. Acta711 (1982) 176.
Tashiro, T., Mashima, Y., Yamamori, H., Horibe, K., Nishizawa, M., Sanada, M., and Okui, K., J. parental ent. Nutr.15 (1991) 546.
Wasan, K. M., Grossie, V. B., and Lopez-Berestein, G., Lab. Anim.28 (1994) 138.
Gueddari, N., Favre, G., Hachem, H., Marek, E., Gaillard, F. L., and Soula, G., Biochimie75 (1993) 811.
Vitols, S., Angelin, B., Ericsson, S., Gahrton, G., Juliusson, G., Masquelier, M., Paul, C., Peterson, C., Rudling, M., Soderberg-Ried, K., and Tidefelt, U., Proc. natl Acad. Sci. USA87 (1990) 2598.
Vitols, S., Gahrton, G., Ost, A., and Peterson, C., Blood63 (1984) 1186.
Ho, Y. K., Smith, R. G., Brown, M. S., and Goldstein, J. L., Blood52 (1978) 1099.
Hynds, S. A., Welsh, J., Stewart, J. M., Jack, A., Soukop, M., Mcardle, C. S., Calman, K. C., Packard, C. J., and Shepherd, J., Biochim. biophys. Acta795 (1984) 589.
Vitols, S., Gahrton, G., Bjorkholm, M., and Peterson, C., Lancetiv (1985) 1150.
Budd, D., and Ginsberg, H., Cancer58 (1986) 1361.
Alexopoulos, C. G., Blatsios, B., and Avgerinos, A., Cancer60 (1987) 3065.
Joly, V., Farinotti, R., Saint-Julien, L., Cheron, M., Carbon, C., and Yeni, P., Antimicrob. Ag. Chemother.38 (1994) 177.
Kirsh, R., Goldstain, R., Tarloff, J., Parris, D., Hook, J., and Hanna, N., J. infect. Dis.158 (1988) 1065.
Moreau, P., Milpied, N., Fayette, N., Ramee, J. F., and Harousseau, J. L., J. antimicrob. Chemother30 (1992) 535.
Venkataram, S., Awni, W. M., Jordan, K., and Rahman, Y. E., J. pharm. Sci.79 (1990) 216.
Grossie, V. B., Nishioka, K., Ota, D. M., and Martin, R. G., Cancer Res.46 (1986) 3463.
Steiger, E., Vars, E. M., and Dudrick, S. J., Archs. Surg.104 (1972) 330.
Turco, S., and King, R. E., in: Sterile Dosage Forms, Their Preparation and Clinical Application, 3rd edn, p. 120. Eds S. Turco and R. E. King, Lea and Febiger, Philadelphia, PA, USA, 1987.
Wasan, K. M., Brazeau, G. A., Keyhani, A., Hayman, A. C., and Lopez-Berestein, G., Antimicrob. Ag. Chemother.37 (1993) 246.
Albers, J. J., Chen, C. H., and Lacko, A. G., Meth. Enzym.129 (1986) 763.
Iverius, P., and Ostlund-Lindqvist, A. M., Meth. Enzym.129 (1986) 691.
Zar, J. H., Biostatistical Analysis, 2nd edn. Prentice-Hall International, Englewood Cliffs, N.J., 1984.
Weinberg, R. B., and Singh, K., Am. J. clin. Nutr.49 (1989) 794.
Hajri, T., Ferezou, J., and Lutton, C., Biochim. biophys. Acta1047 (1990) 121.
Hajri, T., Ferezou, J., Steinmetz, P., and Lutton, C., Biochim. biophys. Acta1166 (1993) 84.
Ney, D. M., Yang, H., Rivera, J., and Lasekan, J. B., J. Nutr.123 (1993) 883.
Amr, S., Hamosh, P., and Hamosh, M., Biochim. biophys. Acta1001 (1989) 145.
Jonas, A., Biochim. biophys. Acta1084 (1991) 205.
Ginsburg, B. E., and Zetterstrom, R., Acta paediat. scand.66 (1977) 39.
Peterson, J., Bihain, B. E., Bengtsson-Olivecronia, G., Deckelbaum, R. J., Carpentier, Y. A., and Olivecronia, T., Proc. natl Acad. Sci. USA87 (1990) 909.
Bayerdorffer, E., Mannes, G. A., Richter, W. O., Ochsenkuhn, T., Seeholzer, G., Kopcke, W., Wiebecke, B., and Paumgartner, G., Ann. inter. Med.118 (1993) 481.
Kritchevsky, S. B., Wilcosky, T. C., Morris, D. L., Troung, K. N., and Tyroler, H. A., Cancer Res.51 (1991) 3198.
Davey-Smith, G., Shipley, M. J., Marriot, M. G., and Rose, G., J. Am. med. Assoc.267 (1992) 70.
Wasan, K. M., Grossie, V. B., and Lopez-Berestein, G., Antimicrob. Ag. Chemother.38 (1994) 2224.
Wasan, K. M., Drugs of the Future19 (1994) 225.
Wasan, K. M., Rosenblum, M. G., Cheung, L., and Lopez-Berestein, G., Antimicrob. Ag. Chemother.38 (1994) 223.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wasan, K.M., Grossie, V.B. Effect of intralipid infusion on serum high- and low-density lipoprotein cholesterol, lecithin: Cholesterol acyltransferase, and lipoprotein lipase in tumor-bearing rats. Experientia 51, 230–234 (1995). https://doi.org/10.1007/BF01931103
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01931103