Liver function tests in patients with computed tomography demonstrated hepatic metastases
Received: 29 April 1988 Accepted: 23 May 1988 DOI:
Cite this article as: Ottmar, M.D., Gonda, R.L., Leithauser, K.J. et al. Gastrointest Radiol (1989) 14: 55. doi:10.1007/BF01889155 Abstract
One hundred patients with computed tomographic (CT) evidence of liver metastases (and confirmation by biopsy or progression of disease) had serum levels of alkaline phosphatase, serum glutamic oxaloacetic transaminase, and serum glutamic pyruvic transaminase measured within two weeks of scanning. All three enzymes were within the normal range in 33% of patients. Even with advanced involvement (defined as three or more metastatic lesions over 3 cm in diameter), 20% of patients had normal levels of all three liver enzymes. Although liver function tests (LFTs) (enzyme levels) are inexpensive and simple to perform, they failed to detect a significant number of patients with liver metastases.
Key words Liver, computed tomography Liver, metastases References
Lind SE, Singer DE: Diagnosing liver metastases: a Bayesian analysis.
J Clin Oncol 4
Tartter PI, Slater G, Gelernt I, Aufses AH: Screening for liver metastases from colorectal cancer with carcinoembryonic antigen and alkaline phosphatase.
Ann Surg 193
Bernardino ME, Thomas JL, Barnes PA, Lewis E: Diagnostic approaches to liver and spleen metastases.
Radiol Clin North Am 20
Temple DF, Parthasarathy KL, Bakshi SP, Mittleman AE: A comparison of isotopic and computerized tomographic scanning in the diagnosis of metastases to the liver in patients with adenocarcinoma of the colon and rectum.
Surg Gynaecol Obstet 156
Mendelsohn ML, Bodansky O: The value of liver function tests in the diagnosis of intrahepatic metastases in the nonicteric cancer patient.
Yesner R, Conn HO: Liver function tests and needle biopsy in the diagnosis of metastatic cancer to the liver.
Ann Intern Med 59
Tempero MA, Petersen RJ, Zetterman RK, Lemon HM, Gurney J: Detection of metastatic liver disease — use of liver scans and biochemical liver tests.
Felix EL, Bagley DH, Sindelar WF et al.: The value of the liver scan in preoperative screening of patients with malignancies.
Nanji AA, Jetha N: Comparison of liver enzymes and liver scan in the detection of hepatic metastases.
J Clin Hematol Oncol 12
Hanks JB, Jones RS: The pathogenesis, detection, and surgical treatment of hepatic metastases.
Curr Probl Cancer 10
Lahr CJ, Soong SJ, Cloud G, Smith JW, Vrist MM, Balch CM: A multifactorial analysis of prognostic factors in patients with liver metastases from colorectal carcinoma.
J Clin Oncol 1
Turonen MJ, Huituri K, Lempinen M: Results of 32 major hepatic resections for primary and secondary malignancies of the liver.
Ann Chir Gynecol 75
Jones RS: Hepatic resection for metastatic cancer.
Surg Ann 17
Hugnier M, Lacaine F: Hepatic metastases in gastrointestinal cancer — diagnostic value of biochemical investigations.
Arch Surg 116
Gunven P, Makuuchi M, Takayasu K, Muriyama N, Yamasaki S, Hasegawa H: Preoperative imaging of liver metastases.
Ann Surg 202
Ranson JHC, Adams PX, Localio SA: Preoperative assessment for hepatic metastases in carcinoma of the colon and rectum.
Surg Gynaecol Obstet 137
Finlay IG, Meek DR, Gray HW, Duncan JG, McArdle CS: Incidence and detection of occult hepatic metastases in colorectal carcinoma.
Br Med J 284
Cedermark BJ, Schultz SS, Bakshi S, Parthasarthy KL, Mittelman A, Evans JT: The value of liver scan in the follow-up study of patients with adenocarcinoma of the colon and rectum.
Surg Gynaecol Obstet 144
Finlay IG, McArdle CS: Role of carcinoembryonic antigen in detection of asymptomatic disseminate disease in colorectal carcinoma.
Br Med J 286
Kemeny MM, Ganteaume L, Goldberg DA, Hogan JM, Terz JJ: Preoperative staging with computerized axial tomography with biochemical laboratory tests in patients with hepatic metastases.
Ann Surg 203
Kemeny MM, Sugarbaker PH, Smith TJ et al.: A prospective analysis of laboratory tests and imaging studies to detect hepatic lesions.
Ann Surg 195
Canal P, Bugat R, Fernet P, Cassigneul J, Soula G: Biological appraisal of liver status in adenocarcinomas.
Helzberg JH, Spiro HM: ‘LFTs’ test more than liver — Editorial.
Gollin FF, Sims JL, Cameron JR: Liver scanning and liver function tests — a comparative study.
Jhingran SG, Jordan L, Johns MF, Haynie TP: Liver scintigrams compared with alkaline phosphatase and BSP determinations in the detection of metastatic carcinoma.
J Nucl Med 12
Kilgore ES, Calabretta AM, Weidner WA, Graham WP: The accuracy of liver scanning in the detection of metastatic disease.
J Surg Oncol 7
Maxfield WS, Ferrante WA, Shuler SE, Leslie CL: A comparison of diagnostic accuracy of liver scans, liver function tests, and liver biopsy.
Prog Clin Cancer 5
Sugarbaker PH, Vermess M, Doppman JL, Miller DL, Simon R: Improved detection of focal lesions with computerized tomography examination of the liver using ethiodized oil emulsion (EOE-13) liver contrast.
Liwendahl K, Schauman KO: Statistical evaluation of liver scanning in combination with liver function tests.
Act Med Scand 192
McGarrity TJ, Samuels T, Wilson FA: An analysis of imaging studies and liver function tests to detect hepatic neoplasia.
Dig Dis Sci 32:1113–1117
Smith TJ, Kemeny MM, Sugarbaker PH et al.: A prospective study of hepatic imaging in the detection of metastatic disease.
Ann Surg 194
Snow JH Jr, Goldstein HM, Wallace S: Comparison of scintigraphy and computed tomography in the evaluation of hepatic neoplasms.
Larroquette CA, Hortobagyi GN, Buzdar AU, Holmes FA: Subclinical hepatic toxicity during combination chemotherapy for breast cancer.
Baden H, Andersen B, Augustenborg G, Hanel HK: Diagnostic value of gamma glutamyl transpeptidase and alkaline phosphatase in liver metastases.
Surg Gynaecol Obstet 133
Mathews J, Slavin JD, Spencer RP: Liver function tests — a study in patients with imaging-demonstrated metastases.
Clin Nucl Med 15
Google Scholar Copyright information
© Springer-Verlag New York Inc. 1989