Original Contributions

Research in Experimental Medicine

, Volume 181, Issue 2, pp 113-123

First online:

Influence of dietary purines on pool size, turnover, and excretion of uric acid during balance conditions

Isotope Studies Using15N-Uric Acid
  • W. LöfflerAffiliated withMedizinische Poliklinik, Universität München
  • , W. GröbnerAffiliated withMedizinische Poliklinik, Universität München
  • , R. MedinaAffiliated withLehrstuhl für allgemeine Chemie und Biochemie, Technischen Universität München
  • , N. ZöllnerAffiliated withMedizinische Poliklinik, Universität München

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Pool size, turnover, and excretion of uric acid were investigated in three normal subjects both during purine-free, isoenergetic liquid formula diet and during additional purine administration by use of isotope dilution techniques. The fractional turnover of the uric acid pool was increased during dietary purine administration suggesting an increased total body uric acid clearance as a result of the increase in renal clearance. Fractional turnover increased more in the female subject than in males, while pool size was increased less. It can be calculated from the results obtained that endogenous uric acid synthesis is not inhibited by dietary purines.

Key words

Uric acid, pool size, turnover, excretion Dietary purines Isotope dilution