Cohort mortality and nested case-control study of lung cancer among structural pest control workers in Florida (United States)
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A previous report on the mortality of this cohort of Florida (United States) pest control workers found the risk of lung cancer was positively associated with the number of years licensed. An additional follow-up (1977–82) of this male cohort confirmed the excess (SMR=1.4) and the rising risk with increasing number of years licensed (SMR=2.2 among workers employed more than 20 years). A nested case-control study was undertaken to determine the effects of smoking and the type of pesticide exposure on lung cancer risk. Occupational histories and other data were obtained on 65 deceased lung cancer cases, 122 deceased controls, and 172 living controls. Interviews were conducted with next-of-kin regardless of the vital status of the subject. Odds ratios (OR) were adjusted by age and smoking. Adjustments for diet and other occupations had no effect on risk estimates and were not included in the final model. Using information from licensing records, ORs for lung cancer were greater for workers first licensed before age 40 (OR=2.4, 95 percent confidence interval [CI]=1.0–5.9 with deceased controls) and increased from 1.4 (CI=0.7–3.0) for subjects licensed 10–19 years to 2.1 (CI=0.8–5.5) for subjects licensed 20 or more years. Using living controls, an association with duration of employment was observed when years of licensure were lagged five years, but was not observed in unlagged analyses. Using information from the questionnaire, the risk of lung cancer was greater among those who worked as pest control operators than non-pest control workers. Although numbers were typically small, lung cancer risk among pest control operators was associated with reported exposure to carbamates, organophosphates, and phenoxyacetic acids and more specifically with diazinon, DDT, carbaryl, and propoxur. These results further suggest that pesticides may play a role in lung cancer risk and underscore the need for research that focuses on specific chemicals.
International Agency for Research on Cancer.Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Supplement 7. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. Lyon, France: IARC, 1987.
International Agency for Research on Cancer.Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Volume 53. Occupational Exposures in Insecticide Application, and Some Pesticides. Lyon, France: IARC, 1991.
Blair A, Axelson O, Franklin C, et al. Carcinogenic effects of pesticides. in: Baker SR, Wilkinson CF, eds.The Effect of Pesticides on Human Health. Princeton, NJ (US): Princeton Scientific Publ. Co., 1990: 201–60.
Blair A, Grauman DJ, Lubin JH, Fraumeni JF Jr.. Lung cancer and other causes of death among licensed pesticide applicators.JNCI 1983;71: 31–7.PubMed
World Health Organization.International Classification of Diseases, Eighth Revision. Geneva, Switzerland: WHO 1967.
Liddell FDK. Simple exact analysis of the standardized mortality ratio.J Epidemiol Commun Health 1984;38: 85–8.
Hosmer DW, Lemeshow S.Applied Logistics Regression. New York, NY (US): John Wiley & Sons, 1989.
Blair A, Steenland K, Shy C, O'Berg M, Halperin W, Thomas T. Control of smoking in occupational epidemiologic studies: Methods and needs.Am J Indust Med 1988;13: 3–4.
Siemiatycki J, Wacholder S, Dewar R, et al. Smoking and degree of occupational exposure: Are internal analyses in cohort studies likely to be confounded by smoking status?Am J Indust Med 1988;13: 59–69.
Boyle CA, Brann EA. Proxy respondents and the validity of occupational and other exposure data.Am J Epidemiol 1992;136: 712–21.PubMed
Johnson RA, Mandel JS, Gibson RW, et al. Data on prior pesticide use collected from self- and proxy respondents.Epidemiology 1993;4: 157–64.PubMed
Brown LM, Dosemeci M, Blair A, Burmeister L. Comparability of data obtained from farmers and surrogate respondents on use of agricultural pesticides.Am J Epidemiol 1991;134: 348–55.PubMed
Friedenreich CM, Slimani N, Riboli E. Measurement of past diet: review of previous and proposed methods.Epidemiol Rev 1992;14: 177–96.PubMed
Checkoway H, Pearce NE, Crawford-Brown DJ.Research Methods in Occupational Epidemiology. New York, NY (US): Oxford University Press, 1989.
Barthel E. Increased risk of lung cancer in pesticide-exposed male agricultural workers.J Toxicol Environ Health 1981;8: 1027–40.PubMed
Kauppinen TP, Partanen TJ, Nurminen MM, et al. Respiratory cancers and chemical exposures in the wood industry: a nested case-control study.Br J Indust Med 1986;43: 84–90.
MacMahon B, Monson RR, Wang HH, Zheng T. A second follow-up of mortality in a cohort of pesticide applicators.J Occup Med 1988;30: 429–32.PubMed
Wang HH, MacMahon B. Mortality of workers employed in the manufacture of chlordane and heptachlor.J Occup Med 1979;21: 745–8.PubMed
Austin H, Keil JE, Cole P. A prospective follow-up study of cancer mortality in relation to serum DDT.Am J Public Health 1989;79: 43–6.PubMed
Ditraglia D, Brown DP, Namekata T, Iverson N. Mortality study of workers employed at organochlorine pesticide manufacturing plants.Scand J Work Environ Health 1981;7: 140–6.PubMed
Wong O, Brocker W, Davis HV, Nagle GS. Mortality of workers potentially exposed to organic and inorganic brominated chemicals, DBCP, TRIS, PBB, and DDT.Br J Indust Med 1984;41: 15–24.
Sathiakumar N, Delzell E, Austin H, Cole P. A follow-up study of agricultural chemical production workers.Am J Indust Med 1992;21: 321–30.
Wicklund KG, Baling JR, Allard J, Weiss NS. Respiratory cancer among orchardists in Washington state, 1968–1980.J Occup Med 1988;30: 561–4.PubMed
Alberghini V, Luberto F, Gobba F, Morelli C, Gori E, Tomesani N. Mortality among male farmers licensed to use pesticides.Med Lav 1991;82: 18–24.PubMed
Cantor KP, Booze CF Jr Mortality among aerial pesticide applicators and flight instructors: a reprint.Arch Environ Health 1991;6: 110–16.
- Cohort mortality and nested case-control study of lung cancer among structural pest control workers in Florida (United States)
Cancer Causes & Control
Volume 5, Issue 4 , pp 310-318
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Brain cancer
- lung cancer
- United States
- Industry Sectors
- Author Affiliations
- 1. Institute of Occupational Health, University of Milan, 20122, Milano, Italy
- 2. Epidemiology and Biostatistics Program, National Cancer Institute, Executive Plaza North, Room 418, 20892, Rockville, MD, USA