Journal of Inherited Metabolic Disease

, Volume 11, Issue 3, pp 285–290

Serotonin and noradrenaline concentrations and serotonin uptake in platelets from hyperphenylalaninaemic patients


  • M. Giovannini
    • 5th Pediatric DepartmentUniversity of
  • R. Valsasina
    • 5th Pediatric DepartmentUniversity of
  • R. Longhi
    • 5th Pediatric DepartmentUniversity of
  • A. M. Cesura
    • Department of PharmacologyUniversity of
  • M. D. Galva
    • Department of PharmacologyUniversity of
  • E. Riva
    • 5th Pediatric DepartmentUniversity of
  • G. P. Bondiolotti
    • Department of PharmacologyUniversity of
  • G. B. Picotti
    • Institute of PharmacologyUniversity of Genoa

DOI: 10.1007/BF01800371

Cite this article as:
Giovannini, M., Valsasina, R., Longhi, R. et al. J Inherit Metab Dis (1988) 11: 285. doi:10.1007/BF01800371


In three untreated patients with phenylketonuria (PKU), three PKU and six hyperphenylalaninaemic (HPA) patients in good metabolic control, the kinetic constants of plateletin vitro uptake of [14C]serotonin (5HT) did not significantly differ from those in 12 control subjects matched for age. The platelet concentrations of endogenous 5HT and noradrenaline (NA), taken as long-term indices of the amount of these amines circulating in plasma, were lower than normal in PKU and HPA patients, whether or not they were kept on a diet. However, a reduction in plasma NA concentrations at the moment of blood collection was seen only in untreated PKU patients. These data indicate that there may be a chronic inhibition of 5HT and possibly of NA synthesis even in PKU or HPA subjects in good metabolic control, with normal psychomotor development and only slightly raised plasma phenylalanine levels.

Download to read the full article text

Copyright information

© SSIEM and MTP Press Limited 1988