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The role of the tubulointerstitial changes in the prognosis of IgA glomerulonephritis

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Summary

The authors investigated the tubulointerstitial changes (atrophic tubuli, interstitial fibrosis and round-cell infiltration) by two methods in renal biopsies from 56 patients with IgA glomerulonephritis. A statistically significant correlation was found to exist between the tubulointerstitial changes and serum creatinine level at the time of renal biopsy. A statistically significant correlation was also established between serum creatinine at the end of a period of 5 years of follow-up and tubulointerstitial changes. Their results suggest that severe tubulointerstitial lesions in IgA glomerulonephritis carry a poor prognosis.

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Abbreviations

GN:

glomerulonephritis

References

  1. Berger J, Hinglais N (1968) Les dépots intercapillaries d'IgA-IgG, J Urol Nephrol 74:694–697

    Google Scholar 

  2. Bohle A, Grund KE, Mackensen S, Tolon M (1977) Correlations between renal interstitium and level of serum creatinine. Virchows Arch (Pathol Anat) 373:15–22

    Google Scholar 

  3. Bohle A, Bader R, Grund KE, Mackensen S, Neunhoeffer J (1977a) Serum creatinine concentration and renal interstitial volume. Analysis of correlations in endocapillary (acute) glomerulonephritis and in moderately severe mesangioproliferative glomerulonephritis. Virchows Arch (Pathol Anat) 375:87–96

    Google Scholar 

  4. Bohle A, Glomb D, Grund KE, Mackensen S (1977b) Correlations between relative interstitial volume of the renal cortex and serum creatinine concentration in minimal change with nephrotic syndrome and in focal sclerosing glomerulonephritis. Virchows Arch (Pathol Anat) 376:221–232

    Google Scholar 

  5. Bohle A, v Gise H, Mackensen-Haen S, Stark-Jakob B (1981) The obliteration of the postglomerular capillaries and its influence upon the function of both glomeruli and tubuli. Klin Wochenschr 59:1043–1051

    Google Scholar 

  6. Clarkson AR, Seymour AE, Thompson AJ, Haynes WDG, Chan Y-L, Jackson B (1977) IgA nephropathy: a syndrome of uniform morphology, diverse clinical features and uncertain prognosis. Clin Nephrol 8:459–471

    Google Scholar 

  7. Croker BP, Dawson DV, Sanfilippo F (1983) IgA nephropathy. Correlation between clinical and histological features. Lab Invest 48:19–24

    Google Scholar 

  8. D'Amico G, Ferrario F, Colasanti G, Ragni A, Bestetti Bosisio M (1981) IgA-mesangial nephropathy (Berger's disease) with rapid decline in renal function. Clin Nephrol 16:251–257

    Google Scholar 

  9. Fischbach H, Mackensen S, Grund KE, Kellner A, Bohle A (1977) Relationship between glomerular lesions, serum creatinine and interstitial volume in membranoproliferative glomerulonephritis. Klin Wochenschr 55:603–608

    Google Scholar 

  10. Gärtner H-V, Hönlein F, Traub U, Bohle A (1979) IgA-nephropathy (IgA-IgG-nephropathy/IgA nephritis) — a disease entity? Virchows Arch (Pathol Anat) 385:1–27

    Google Scholar 

  11. Mackensen S, Grund KE, Bader R, Bohle A (1977) The influence of glomerular and interstitial factors on the serum creatinine concentration in renal amyloidosis. Virchows Arch (Pathol Anat) 375:159–168

    Google Scholar 

  12. Mackensen-Haen S, Grund KE, Schirmeister J, Bohle A (1979) Impairment of the glomerular filtration rate by glomerular and interstitial factors in membranoproliferative glomerulonephritis with normal serum creatinine concentration. Virchows Arch (Pathol Anat) 382:11–19

    Google Scholar 

  13. Mackensen-Haen S, Bader R, Grund KE, Bohle A (1981) Correlations between renal cortical interstitial fibrosis, atrophy of the proximal tubules and impairment of the glomerular filtration rate. Clin Nephrol 15:167–181

    Google Scholar 

  14. Morel-Maroger L, Leathem A, Richet G (1972) Glomerular abnormalities in nonsystemic diseases. Relationship between findings by light microscopy and immunofluorescence in 443 renal biopsy specimens. Am J Med 53:170–184

    Google Scholar 

  15. Nagy J (1981) Clinicopathological, immunological and etiopathogenetical examinations in IgA glomerulonephritis. Thesis, Pécs

  16. Nagy J, Brasch H, Trinn Cs, Burger T (1982) Clinical features and course of IgA glomerulonephritis. Acta Med Acad Sci Hung 39:201–210

    Google Scholar 

  17. Riemenschneider T, Mackensen-Haen S, Christ H, Bohle A (1980) Correlation between endogenous creatinine clearance and relative interstitial volume of the renal cortex in patients with diffuse membranous glomerulonephritis having a normal serum creatinine concentration. Lab Invest 43:145–149

    Google Scholar 

  18. Risdon RA, Sloper JC, de Wardener HE (1968) Relationship between renal function and histologic changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet 2:363–366

    Google Scholar 

  19. Schainuck LI, Striker GE, Luther RE, Benditt EP (1970) Structural-functional correlations in renal disease. II. The correlations. Hum Pathol 1:631–641

    Google Scholar 

  20. Sissons JGP, Woodrow DF, Curtis JR, Evans DJ, Gower PE, Sloper JC (1975) Isolated glomerulonephritis with mesangial IgA-deposits. Br Med J 3:611–614

    Google Scholar 

  21. Thoenes GH (1976) The immunohistology of glomerulonephritis — distinctive marks and variability. Curr Top Pathol 61:61–106

    Google Scholar 

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Authors and Affiliations

  1. Second Department of Medicine, University Medical School, Pécs, Hungary

    J. Nagy, C. Trinn & T. Burger

  2. Department of Pathology, University Medical School, Pécs, Hungary

    G. Deák

  3. Central Laboratory of Sciences, University Medical School, Pécs, Hungary

    M. Schmelzer

Authors
  1. J. Nagy
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  2. C. Trinn
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  3. G. Deák
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  4. M. Schmelzer
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  5. T. Burger
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Nagy, J., Trinn, C., Deák, G. et al. The role of the tubulointerstitial changes in the prognosis of IgA glomerulonephritis. Klin Wochenschr 62, 1094–1096 (1984). https://doi.org/10.1007/BF01711380

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  • DOI: https://doi.org/10.1007/BF01711380

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