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Effects of the organophosphate insecticide, monocrotophos, on acetylcholinesterase activity in the nile tilapia fish (Oreochromis niloticus) brain

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Abstract

The neurotoxic effects of monocrotophos on the brain of the nile tilapia fish (Oreochromis niloticus) were examined, using a static bioassay under laboratory conditions. By probit analysis the 96 h LC50 value of monocrotophos was 4.9 mg/l. After 96 h exposure to acute levels of monocrotophos, the brain acetylcholinesterase (AChE) activity decreased progressively as the concentration of monocrotophos increased. In addition, four weeks following transfer to toxicant-free water after exposure to 1 mg monocrotophos, nile tilapia fish brain regained 95% of control AChE activity. The results indicate that inhibition of AChE activity in fish exposed to monocrotophos may serve as an indicator of hazard due to application of this chemical in the natural environment.

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Authors and Affiliations

  1. Neuro-Behavioural Biology Center, Institute of Science and Technology for Development, Mahidol University, Salaya Campus, 73170, Nakornpathom, Thailand

    Wipawan Thangnipon & Pinsuda Luangpaiboon

  2. Agricultural Toxic Substances Division, Department of Agriculture, Chatuchak, 10900, Bangkok, Thailand

    Wipa Thangnipon

  3. Aquatic Animal Health Research Institute, Department of Fisheries, Kasetsart University Campus, Chatuchak, 10900, Bangkok, Thailand

    Supranee Chinabut

Authors
  1. Wipawan Thangnipon
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  2. Wipa Thangnipon
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  3. Pinsuda Luangpaiboon
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  4. Supranee Chinabut
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Special issue dedicated to Dr. Robert Balazs.

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Thangnipon, W., Thangnipon, W., Luangpaiboon, P. et al. Effects of the organophosphate insecticide, monocrotophos, on acetylcholinesterase activity in the nile tilapia fish (Oreochromis niloticus) brain. Neurochem Res 20, 587–591 (1995). https://doi.org/10.1007/BF01694540

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