Skip to main content
SpringerLink
Log in

The ratio of acetylcholinesterase to butyrylcholinesterase influences the specificity of assays for each enzyme in human brain

  • Original Papers
  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

A single-vial extraction radiometric assay was used to measure acetylcholinesterase and butyrylcholinesterase in human post-mortem brain tissue. Data are presented regarding the differential inhibition of acetylcholinesterase and butyrylcholinesterase in several brain areas from a case of Alzheimer's disease and a case without neuropsychiatrie disease. The results indicate that neither enzyme is entirely specific for its substrate, and the necessity for using inhibitors depends upon the ratio of acetylcholinesterase to butyrylcholinesterase in a particular sample.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Departments of Psychiatry and Neurology, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, Pennsylvania

    F. J. Huff & C. T. Reiter

  2. Department of Zoology, University of Wisconsin, Madison, Wisconsin, USA

    J. B. Rand

Authors
  1. F. J. Huff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. T. Reiter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. B. Rand
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Huff, F.J., Reiter, C.T. & Rand, J.B. The ratio of acetylcholinesterase to butyrylcholinesterase influences the specificity of assays for each enzyme in human brain. J. Neural Transmission 75, 129–134 (1989). https://doi.org/10.1007/BF01677426

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01677426

Keywords

Search

Navigation