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Comparative histogenesis and morphogenesis of mucoepidermoid carcinoma and pleomorphic adenoma

An ultrastructural study

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Summary

Current classifications of salivary gland tumors separate mucoepidermoid carcinoma from other neoplasms on the basis of a number of histological features, in particular the lack of participation of neoplastic myoepithelial cells. However, ultrastructural examination of low- and intermediate-grade mucoepidermoid carcinomas and pleomorphic adenomas reveals many common organizational and cellular features. Of prime importance is the relationship of intermediate cells to the luminal cells in mucoepidermoid carcinomas, which is remarkably similar to that seen between modified myoepithelial cells and luminal cells in pleomorphic adenomas. The results suggest that intermediate cells of mucoepidermoid carcinoma are the counterpart of the modified myoepithelial cells of pleomorphic adenoma. The generally accepted hypothesis that the former tumor develops from an excretory duct reserve cell, while the latter originates from an intercalated duct stem cell does not seem to be valid; pleomorphic adenoma and mucoepidermoid carcinoma appear to be closely related morphologically.

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References

  • Accetta PA, Gray GF, Hunter RM, Rosenfeld L (1984) Mucoepidermoid carcinoma of salivary glands. Arch Pathol Lab Med 108:321–325

    Google Scholar 

  • Barka T (1965) Induced cell proliferation: the effect of isoproterenol. Exp Cell Res 37:662–679

    Google Scholar 

  • Batsakis JG (1980) Salivary gland neoplasia: an outcome of modified morphogenesis and cytodifferentiation. Oral Surg 49:229–232

    Google Scholar 

  • Batsakis JG (1985) Editorial note. Head Neck Surg 7:394

    Google Scholar 

  • Batsakis JG, Luna MA (1989) Low-grade and high-grade adenocarcinomas of the salivary duct system. Ann Otol Rhinol Laryngol 198:162–163

    Google Scholar 

  • Batsakis JG, Kraemer B, Sciubba J (1983) The pathology of head and neck tumors: the myoepithelial cell and its participation in salivary gland neoplasia, part 17. Head Neck Surg 5:222–233

    Google Scholar 

  • Batsakis JG, Ordóñez NG, Ro J, Meis JM, Bruner JM (1986) S-100 protein and myoepithelial neoplasms. J Laryngol Otol 100:687–698

    Google Scholar 

  • Batsakis JG, Regezi JA, Luna MA, El-Naggar A (1989) Histogenesis of salivary gland neoplasms: a postulate with prognostic implications. J Laryngol Otol 103:939–944

    Google Scholar 

  • Born LA, Schwechheimer K, Maier H, Otto HF (1987) Cytokeratin expression in normal salivary glands and in cystadenolymphomas demonstrated by monoclonal antibodies directed against selected cytokeratin polypeptides. Virchows Arch [A] 411:583–589

    Google Scholar 

  • Burns BF, Dardick I, Parks WR (1988) Intermediate filament expression in normal parotid glands and pleomorphic adenomas. Virchows Arch [A] 403:103–112

    Google Scholar 

  • Chaudhry AP, Cutler LS, Yamane GM, Labay GR, SunderRaj M, Manak JR (1987) Ultrastructure of normal human parotid gland with special emphasisis on myoepithelial distribution. J Anat 152:1–11

    Google Scholar 

  • Chaudhry AP, Cutler LS, Liefer C, Labay G, Satchidanand S, Yamane M (1989) Ultrastructural study of the histogenesis of salivary gland mucoepidermoid carcinoma. J Oral Pathol Med 18:400–409

    Google Scholar 

  • Chen S-Y (1979) Ultrastructure of mucoepidermoid carcinomas in minor salivary glands. Oral Surg 47:247–255

    Google Scholar 

  • Chomette G, Auriol M, Tereau Y, Vaillant JM (1982) Les tumeurs mucoepidermoides des glandes salivaires accessoires: Denombrement. Etude clinico-pathologique, histoenzymologique et ultrastructurale. Ann Pathol (Paris) 2:29–40

    Google Scholar 

  • Conley J, Tinsley PP Jr (1985) Treatment and prognosis of mucoepidermoid carcinoma in the pediatric age group. Arch Otolaryngol 111:322–324

    Google Scholar 

  • Cutler LS, Chaudhry A, Innes DJ Jr (1977) Ultrastructure of the parotid duct. Cytochemical studies of the striated duct and papillary cystadenoma lymphomatosum of the human parotid gland. Arch Pathol Lab Med 101:420–424

    Google Scholar 

  • Dardick I, van Nostrand AWP (1985) Myoepithelial cells in salivary gland tumors — revisited. Head Neck Surg 7:395–408

    Google Scholar 

  • Dardick I, van Nostrand AWP (1987) Morphogenesis of salivary gland tumors: a prerequisite to improving classification. Pathol Annu 22:1–53

    Google Scholar 

  • Dardick I, van Nostrand AWP, Jeans MTD, Rippstein P, Edwards V (1983a) Pleomorphic adenoma. I. Ultrastructural organization of “epithelial” regions. Hum Pathol 14:780–797

    Google Scholar 

  • Dardick I, van Nostrand AWP, Jeans MTD, Rippstein P, Edwards V (1983b) Pleomorphic adenoma. II. Ultrastructural organization of “stromal” regions. Hum Pathol 14:798–809

    Google Scholar 

  • Dardick I, Daya D, Hardie J, van Nostrand AWP (1984) Mucoepidermoid carcinoma: ultrastructural and histogenetic aspects. J Oral Pathol 13:342–358

    Google Scholar 

  • Dardick I, Rippstein P, Skimming L, Boivin M, Dairkee SH (1987) Immunohistochemistry and ultrastructure of myoepithelium and modified myoepithelium of the ducts of human major salivary glands: histogenetic implications for salivary gland tumors. Oral Surg 64:703–715

    Google Scholar 

  • Dardick I, Parks WR, Little J, Brown DL (1988) Characterization of cytoskeletal proteins in basal cells of human parotid salivary gland ducts. Virchows Arch [A] 412:525–532

    Google Scholar 

  • Dardick I, Hardie J, Thomas MJ, van Nostrand AWP (1989a) Ultrastructural contributions to the study of morphological differentiation in malignant mixed (pleomorphic) tumors of salivary gland. Head Neck Surg 11:5–21

    Google Scholar 

  • Dardick I, Thomas MJ, van Nostrand AWP (1989b) Myoepithelioma — new concepts of histology and classification: a light and electron microscopic study. Ultrastruct Pathol 13:187–224

    Google Scholar 

  • Dardick I, Byard RW, Carnegie JA (1990) A review of proliferative capacity of major salivary glands and the relationship to current concepts of neoplasia in salivary gland. Oral Surg Oral Med Oral Pathol 69:53–67

    Google Scholar 

  • Erlandson RA, Cardon-Cardo C, Higgins PJ (1984) Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands: an ultrastructural and immunohistochemical study. Am J Surg Pathol 8:803–820

    Google Scholar 

  • Evans HL (1984) Mucoepidermoid carcinoma of salivary glands: A study of 69 cases with special attention to histologic grading. Am J Clin Pathol 81:696–701

    Google Scholar 

  • Eversole LR (1971) Histogenetic classification of salivary gland tumors. Arch Pathol 92:433–443

    Google Scholar 

  • Geiger S, Geiger B, Leitner O, Marshak G (1987) Cytokeratin polypeptides expression in different epithelial elements in human salivary glands. Virchows Arch [A] 410:403–414

    Google Scholar 

  • Gustafsson H, Virtanen I, Thornell L-E (1989) Glial fibrillary acidic protein and desmin in salivary gland neoplasms: expression of four different types of intermediate filament proteins within the same cell type. Virchows Arch [B] 57:303–313

    Google Scholar 

  • Hamper K, Schmitz-Watjen W, Mausch H-E, Caselitz J, Seifert G (1989) Multiple expression of tissue markers in mucoepidermoid carcinomas and acinic cell carcinomas of the salivary glands. Virchows Arch [A] 414:407–413

    Google Scholar 

  • Hamper K, Schimmelpenning H, Caselitz J, Arps H, Berger J, Askensten U, Auer G, Seifert G (1989) Mucoepidermoid tumors of the salivary glands. The prognostic relevance of DNA cytophotometry in a retrospective study of long duration (1965–1987). Cancer 63:708–717

    Google Scholar 

  • Hanna W, Kahn HJ (1985) Ultrastructural and immunohistochemical characteristics of mucoepidermoid carcinoma of the breast. Hum Pathol 16:941–946

    Google Scholar 

  • Healey WV, Perzin KH, Smith L (1970) Mucoepidermoid carcinoma of salivary gland origin. Cancer 26:368–388

    Google Scholar 

  • Hubner G, Kleinsasser O (1979) Zur feinstruktur und genese des mucoepidermoidtumors der speicheldrusen. Virchows Arch [A] 349:281–296

    Google Scholar 

  • Jensen OJ, Poulsen T, Schiodt T (1988) Mucoepidermoid tumors of salivary glands: a long term follow-up study. APMIS 96:421–427

    Google Scholar 

  • Kumasa S, Yuba R, Sagara S, Okutomi T, Okada Y, Mori M (1988) Mucoepidermoid carcinomas: immunohistochemical studies on keratin, S-100 protein, lactoferrin, lysozyme and amylase. Basic Appl Histochem 32:429–441

    Google Scholar 

  • Klacsmann PG, Olson JL, Eggleston JC (1979) Mucoepidermoid carcinoma of the bronchus. An electron microscopic study of the low grade and the high grade variants. Cancer 43:1720–1733

    Google Scholar 

  • Lam RMY (1984) An electron microscopic histochemical study of the histogenesis of major salivary gland pleomorphic adenoma. Ultrastruct Pathol 8:207–223

    Google Scholar 

  • Leoncini P, Cintorino M, Vindigni C, Leoncini L, Armellini D, Bugnoli M, Skalli O, Gabbiani G (1988) Distribution of cytoskeletal and contractile proteins in normal and tumor bearing salivary and lacrimal glands. Virchows Arch [A] 412:329–337

    Google Scholar 

  • Miura K, Ishimaru Y, Yoshimura T (1986) Light and electron microscopic study of mucoepidermoid tumor of clear cell type. Acta Pathol Jpn 36:1419–1427

    Google Scholar 

  • Mori M, Tsukitani K, Ninomiya T, Okada Y (1987) Various expressions of modified myoepithelial cells in salivary pleomorphic adenoma. Pathol Res Pract 182:632–646

    Google Scholar 

  • Nikai H, El-Bardaie AM, Takata T, Ogawa I, Ijuhin N (1986) Histologic evaluation of myoepithelial cell participation in salivary gland tumors. Int J Oral Maxillofac Surg 15:597–605

    Google Scholar 

  • Nicolatou O, Harwick RD, Putong P, Leifer C (1979) Ultrastructural characterization of intermediate cells of mucoepidermoid carcinoma of parotid. Oral Surg 48:324–336

    Google Scholar 

  • Orenstein JM, Dardick I, van Nostrand AWP (1985) Ultrastructural similarities of adenoid cystic carcinoma and pleomorphic adenoma. Histopathology 9:623–638

    Google Scholar 

  • Palmer RM, Lucas RB, Langdon GD (1985) Ultrastructural analysis of salivary gland pleomorphic adenoma, with particular reference to myoepithelial cells. Histopathology 9:1061–1076

    Google Scholar 

  • Regezi JA, Batsakis JG (1977) Histogenesis of salivary gland neoplasms. Otolaryngol Clin North Am 10:297–307

    Google Scholar 

  • Spiro RH, Huvos AG, Berk R, Strong EW (1978) Mucoepidermoid carcinoma of salivary gland origin: a clinicopathologic study of 367 cases. Am J Surg 136:461–468

    Google Scholar 

  • Thackray AC, Lucas RB (1974) Tumors of the major salivary glands. Atlas of tumor pathology, 2nd series, fasc. 10. Washington DC, Armed Forces Institute of Pathology, pp 69–80

    Google Scholar 

  • Tomita T, Lotuaco L, Talbott L, Watanabe I (1977) Mucoepidermoid carcinoma of the subglottis; an ultrastructural study. Arch Pathol Lab Med 101:145–148

    Google Scholar 

  • Walker NI, Gobe GC (1987) Cell death and cell proliferation during atrophy of the rat parotid gland induced by duct obstruction. J Pathol 153:333–344

    Google Scholar 

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Dardick, I., Gliniecki, M.R., Heathcote, J.G. et al. Comparative histogenesis and morphogenesis of mucoepidermoid carcinoma and pleomorphic adenoma. Vichows Archiv A Pathol Anat 417, 405–417 (1990). https://doi.org/10.1007/BF01606029

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  • DOI: https://doi.org/10.1007/BF01606029

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