Origins of Life and Evolution of the Biosphere

, Volume 25, Issue 1, pp 47-52

First online:

Specific effect of magnesium ion on 2′, 3′-cyclic amp synthesis from adenosine and trimeta phosphate in aqueous solution

  • Y. YamagataAffiliated withDepartment of Physics, Kanazawa Institute of Technology
  • , H. InoueAffiliated withDepartment of Physics, Kanazawa University
  • , K. InomataAffiliated withDepartment of Chemistry, Kanazawa University

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Phosphorylation of adenosine by trimetaphosphate was investigated using various catalysts in aqueous solution under mild conditions at pH ∼ 7.0 and at 41 °C. The product was primarily 2′,3′-cyclic AMP together with smaller amounts of ATP. Magnesium ion was found to have a remarkable catalytic effect of approximately one hundred times greater than the other chemicals tested. The mechanism for the specific effect of magnesium ion is discussed.