Origins of Life and Evolution of the Biosphere

, Volume 25, Issue 1, pp 47–52

Specific effect of magnesium ion on 2′, 3′-cyclic amp synthesis from adenosine and trimeta phosphate in aqueous solution


  • Y. Yamagata
    • Department of PhysicsKanazawa Institute of Technology
  • H. Inoue
    • Department of PhysicsKanazawa University
  • K. Inomata
    • Department of ChemistryKanazawa University

DOI: 10.1007/BF01581572

Cite this article as:
Yamagata, Y., Inoue, H. & Inomata, K. Origins Life Evol Biosphere (1995) 25: 47. doi:10.1007/BF01581572


Phosphorylation of adenosine by trimetaphosphate was investigated using various catalysts in aqueous solution under mild conditions at pH ∼ 7.0 and at 41 °C. The product was primarily 2′,3′-cyclic AMP together with smaller amounts of ATP. Magnesium ion was found to have a remarkable catalytic effect of approximately one hundred times greater than the other chemicals tested. The mechanism for the specific effect of magnesium ion is discussed.

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© Kluwer Academic Publishers 1995