Dopamine-beta-hydroxylase (DBH) and homovanillic acid (HVA) in autistic children
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- Garnier, C., Comoy, E., Barthelemy, C. et al. J Autism Dev Disord (1986) 16: 23. doi:10.1007/BF01531575
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In the present study, plasma DBH activity and urinary HVA levels were measured in 19 autistic and 15 normal children. DBH activity was significantly elevated in the 8 less retarded autistic patients. In this subgroup, a negative correlation was found between plasma DBH and urinary HVA levels. These results support the hypothesis of a possible involvement of brain catecholamine dysfunction in the production of autistic symptoms.