Journal of Autism and Developmental Disorders

, Volume 16, Issue 1, pp 23–29

Dopamine-beta-hydroxylase (DBH) and homovanillic acid (HVA) in autistic children

Authors

  • C. Garnier
    • Laboratoire de Neurophysiologie et de Thérapeutique en PédopsychiatrieC. H. U. Bretonneau
  • E. Comoy
    • Unité de Biologie CliniqueInstitut Gustave Roussy
  • C. Barthelemy
    • Laboratoire de Neurophysiologie et de Thérapeutique en PédopsychiatrieC. H. U. Bretonneau
  • I. Leddet
    • Laboratoire de Neurophysiologie et de Thérapeutique en PédopsychiatrieC. H. U. Bretonneau
  • B. Garreau
    • Laboratoire de Neurophysiologie et de Thérapeutique en PédopsychiatrieC. H. U. Bretonneau
  • J. P. Muh
    • Laboratoire de Neurophysiologie et de Thérapeutique en PédopsychiatrieC. H. U. Bretonneau
  • G. Lelord
    • Laboratoire de Neurophysiologie et de Thérapeutique en PédopsychiatrieC. H. U. Bretonneau
Article

DOI: 10.1007/BF01531575

Cite this article as:
Garnier, C., Comoy, E., Barthelemy, C. et al. J Autism Dev Disord (1986) 16: 23. doi:10.1007/BF01531575

Abstract

In the present study, plasma DBH activity and urinary HVA levels were measured in 19 autistic and 15 normal children. DBH activity was significantly elevated in the 8 less retarded autistic patients. In this subgroup, a negative correlation was found between plasma DBH and urinary HVA levels. These results support the hypothesis of a possible involvement of brain catecholamine dysfunction in the production of autistic symptoms.

Copyright information

© Plenum Publishing Corporation 1986