Zonation of metabolism and gene expression in liver
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- Jungermann, K. Histochem Cell Biol (1995) 103: 81. doi:10.1007/BF01454004
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The zonation of gene expression resulting in the different cellular equipment of liver cells with enzymes, translocators and subcellular structures is regulated mainly at a pretranslational level. In the dynamic zonation of carbohydrate metabolizing enzymes, gradients in oxygen and in the glucagon/insulin ratio decreasing from the periportal to the perivenous area appear to be major effectors. In the stable zonation of ammonia-metabolizing enzymes local paracrine cell-cell interactions via diffusible mediators could play a major role (Fig. 6).