Histochemistry and Cell Biology

, Volume 103, Issue 2, pp 81–91

Zonation of metabolism and gene expression in liver

  • Kurt Jungermann

DOI: 10.1007/BF01454004

Cite this article as:
Jungermann, K. Histochem Cell Biol (1995) 103: 81. doi:10.1007/BF01454004


The zonation of gene expression resulting in the different cellular equipment of liver cells with enzymes, translocators and subcellular structures is regulated mainly at a pretranslational level. In the dynamic zonation of carbohydrate metabolizing enzymes, gradients in oxygen and in the glucagon/insulin ratio decreasing from the periportal to the perivenous area appear to be major effectors. In the stable zonation of ammonia-metabolizing enzymes local paracrine cell-cell interactions via diffusible mediators could play a major role (Fig. 6).

Copyright information

© Springer Verlag 1995

Authors and Affiliations

  • Kurt Jungermann
    • 1
  1. 1.Institut für Biochemie und Molekulare ZellbiologieGeorg-August UniversitätGöttingenGermany