Skip to main content
Log in

Fibrosarcoma of the scalp following postoperative radiotherapy for medulloblastoma

  • Special Cases
  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

A rare case of fibrosarcoma of the scalp following postoperative radiotherapy for medulloblastoma is reported. A review of similar cases in the literature was undertaken in an attempt to find a correlation between the dose of radiation, the length of the latent period, and the nature of the neoplasm. A significantly shorter latent period was found for sarcomas. No relationship was observed between the radiation dose and the latent period. The present case is unique in that the post-irradiation neoplasm (PIN) occurred in a predominantly extracranial site after treatment for a desmoplastic medulloblastoma and had a remarkably short latent period.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Anderson JR, Treip CS (1984) Radiation induced intracranial neoplasms: A report of three possible cases. Cancer 53: 426–429

    PubMed  Google Scholar 

  2. Bogdanowicz WM, Sachs E Jr (1974) The possible role of radiation on oncogenesis of meningioma. Surg Neurol 2: 379–383

    PubMed  Google Scholar 

  3. Cohen MS, Kushner MJ, Dell S (1981) Frontal lobe astrocytoma following radiotherapy for medulloblastoma. Neurology (NY) 31: 616–619

    Google Scholar 

  4. Elaine R, Modan B, Boice JD, Alfandary E, Stovall M, Chetrit A, Katz L (1988) Tumours of the brain and nervous system after radiotherapy in childhood. N Engl J Med 319: 1033–1039

    PubMed  Google Scholar 

  5. Hatfield PM, Schulz MD (1970) Postirradiation sarcoma. Radiol 96: 593–602

    Google Scholar 

  6. Hsu SM, Raine L, Fanger M (1981) A comparative study of the peroxidase antiperoxidase method and an avidin biotin complex method for studying polypeptide hormone with radioimmunoassay antibodies. Am J Clin Path 75: 734–738

    PubMed  Google Scholar 

  7. Iacono RP, Apuzzo MLJ, Davis RL, Tsai FY (1981) Multiple meningiomas following radiation therapy for medulloblastoma. J Neurosurg 55: 282–286

    PubMed  Google Scholar 

  8. Kim JH, Chu FC, Woodard HQ, Melamed MR, Huvos A, Cantin J (1978) Radiation induced soft tissue and bone sarcoma. Radiol 129: 501–508

    Google Scholar 

  9. Kleriga E, Sher JH, Nallainathan SK, Stein SC, Sacher M (1978) Development of cerebellar malignant astrocytoma at site of a medulloblastoma treated 11 years earlier. J Neurosurg 49: 445–449

    PubMed  Google Scholar 

  10. Kumar PP, Good RR, Skultety FM, Leibrock LG, Severson GS (1987) Radiation induced neoplasm of the brain. Cancer 59: 1274–1282

    PubMed  Google Scholar 

  11. Laskin WB, Silverman TA, Enzinger FM (1988) Postradiation soft tissue sarcomas. Cancer 62: 2330–2340

    PubMed  Google Scholar 

  12. Leader M, Collins M, Patel J, Henry K (1987) Vimentin: An evaluation of its role as a tumour marker. Histopathol 11: 63–72

    Google Scholar 

  13. Li FP, Cassady JR, Jaffe N (1975) Risks of second tumors in survivors of childhood cancer. Cancer 35: 1230–1235

    PubMed  Google Scholar 

  14. Maldague P (1969) Comparative study experimentally induced cancer of the kidney in mice and rats with X-ray. In: International Atomic Energy Agency Symposium: Radiation induced cancer, IAEA, Vienna, pp 439–458

    Google Scholar 

  15. Montanera W, Chui M, Hudson A (1985) Meningioma and occlusive vasculopathy: Coexisting complications of past extracranial radiation. Surg Neurol 24: 35–39

    PubMed  Google Scholar 

  16. Noetzli M, Malamud N (1962) Postradiation fibrosarcoma of the brain. Cancer 15: 617–622

    PubMed  Google Scholar 

  17. Norwood CW, Kelly DL, Davis CH, Alexander E (1974) Irradiation induced mesodermal tumours of the central nervous system. Surg Neurol 2: 161–164

    PubMed  Google Scholar 

  18. Park TS, Hoffman HJ, Hendrick EB, Humphreys RP, Becker LE (1983) Medulloblastoma: Clinical presentation and management. J Neurosurg 58: 543–552

    PubMed  Google Scholar 

  19. Pearl GS, Mirra SS, Miles ML (1980) Glioblastoma multiforme occurring 13 years after treatment of a medulloblastoma. Neurosurgery 6: 546–551

    PubMed  Google Scholar 

  20. Preston-Martin S, Yu MC, Henderson BE, Roberts C (1983) Risk factors for meningiomas in men in Los Angeles County. JNCI 70: 863–866

    PubMed  Google Scholar 

  21. Robinson RG (1978) A second brain tumour and irradiation. J Neurol Neurosurg Psychiatry 41: 1005–1012

    PubMed  Google Scholar 

  22. Waltz TA, Brownell B (1966) Sarcoma: A possible late result of effective radiation therapy for pituitary adenoma. J Neurosurg 24: 901–907

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Prasad, M.L., Mahapatra, A.K., Dinda, A.K. et al. Fibrosarcoma of the scalp following postoperative radiotherapy for medulloblastoma. Acta neurochir 109, 145–149 (1991). https://doi.org/10.1007/BF01403011

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01403011

Keywords

Navigation